Ataxia Female, 59 years old, March – April 2018


Diagnosis Sex Age Nationality
Ataxia Female 59 years Australian
Injections Cell type Admission date Discharge date
8 UCBSC 2018-03-15 2018-04-08

Condition On Admission

The patient was diagnosed with ataxia in May 2017. At treatment admission she had an unsteady gait and general balance problems. She had to use a walker to move around.

Treatment Schedule

Patient received 6 umbilical cord blood-derived stem cell (UCBSC) packets by intravenous (IV) injection and lumbar puncture (LP), as per the schedule below:

Number Date Cell Type Delivery Method Side Effects
1 2018-03-16 UCBSC Intravenous Injection none reported
2 2018-03-20 UCBSC Intrathecal Injection none reported
3 2018-03-23 UCBSC Intrathecal Injection none reported
4 2018-03-26 UCBSC Intrathecal Injection none reported
5 2018-03-30 UCBSC Intrathecal Injection &
Intravenous Injection
none reported
6 2018-04-04 UCBSC Intrathecal Injection &
Intravenous Injection
none reported

Condition 1 month after treatment

Condition at 1 month after treatment: ​The patient reported small improvements, mostly in coordination, balance, walking, fine hand movements including handwriting and overall general physical health. The patient’s local noticed how well she was walking compared to before the treatment.

Condition 6 months after treatment

Condition at 6 months after treatment: ​The patient reported moderate improvements. She would now walk independently and was able carry things e.g. a tea cup, a dinner plate or a washing basket. Her local doctor mentioned that her balance and walking had improved.

Condition 12 months after treatment

Condition at 12 months after treatment: ​The patient mentions that she had important improvements since the end of the treatment. She is now able to walk unassisted with much better balance and she feels like the improvements have reached their peak and are stable. The patient’s local doctor confirmed that she was now able to walk unassisted.

Parents’ Assessment of Improvement
Significant improvement
Control of movement
Significant improvement
Fine hand movements
Significant improvement
Significant improvement
Significant improvement


  1. Human Umbilical Cord Blood Derived Mononuclear Cell Transplantation Case Series of 30 Subjects with Hereditary Ataxia
  2. Hyun-Jung Park,Giyoon Bang, Bo Ra Lee, Hyun Ok Kim, and Phil Hyu Lee. Neuroprotective Effect of Human Mesenchymal Stem Cells in an AnimalModel of Double Toxin-Induced Multiple System Atrophy Parkinsonism. Cell Transplantation, Vol. 20, pp. 827–835, 2011.
  3. Zhongling Feng & Feng Gao. Stem Cell Challenges in the Treatment of Neurodegenerative Disease. CNS Neuroscience & Therapeutics 00 (2011) 1–7.
  4. You-Kang Chang, Ming-Hsiang Chen, Yi-Hung et al. Mesenchymal stem cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cells.
  5. Kevin Kemp,Elizabeth Mallam, Kelly Hares, Jonathan Witherick, Neil Scolding, and Alastair Wilkins. Mesenchymal Stem Cells Restore Frataxin Expression and Increase Hydrogen Peroxide Scavenging Enzymes in Friedreich Ataxia Fibroblasts.