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Ataxia Male, 35 years old, May – June 2018

Summary

Diagnosis Sex Age Nationality
Ataxia Male 35 years Indian
Injections Cell type Admission date Discharge date
9 UCBSC 2018-05-29 2018-06-19

Condition On Admission

The patient’s chief complaint was an unstable gait, Inability to walk without watching one’s feet, Excessive fatigue, High level of difficulty in climbing up and down stairs even with support, Inability to run or jump, Pain in the limbs after walking or standing for even a very short distance/time, Slight slurring of speech when tired.

Treatment Schedule

Patient received 6 umbilical cord blood-derived stem cell (UCBSC) packets by intravenous (IV) injection and lumbar puncture (LP), as per the schedule below:

Number Date Cell Type Delivery Method Side Effects
1 2018-05-30 UCBSC Intravenous Injection none reported
2 2018-06-01 UCBSC Intravenous Injection &
Intravenous Injection
none reported
3 2018-06-07 UCBSC Intrathecal Injection &
Intravenous Injection
none reported
4 2018-06-11 UCBSC Intrathecal Injection &
Intrathecal Injection
none reported
5 2018-06-11 UCBSC Intrathecal Injection &
Intrathecal Injection
none reported

Condition 1 month after treatment

Condition 1 month after treatment: ​The patient mentioned that he could walk for longer period of times.

Condition 6 months after treatment

Condition 6 months after treatment: ​The patient mentions that he started to feel a regression of his improvements at 2 months after the treatment, He believes that most of the improvements he had are

Symptom
Parents’ Assessment of Improvement
Balance
Moderate improvements
Coordination
Moderate improvements
Fine hand movements
Small improvements
Tremors
Not applicable
Control of movement
Moderate improvements
Muscle stiffness
Not applicable
Speech
Moderate improvements
Walking
Moderate improvements
Fatigue
Small improvements

References

  1. Human Umbilical Cord Blood Derived Mononuclear Cell Transplantation Case Series of 30 Subjects with Hereditary Ataxia
  2. Hyun-Jung Park,Giyoon Bang, Bo Ra Lee, Hyun Ok Kim, and Phil Hyu Lee. Neuroprotective Effect of Human Mesenchymal Stem Cells in an AnimalModel of Double Toxin-Induced Multiple System Atrophy Parkinsonism. Cell Transplantation, Vol. 20, pp. 827–835, 2011.
  3. Zhongling Feng & Feng Gao. Stem Cell Challenges in the Treatment of Neurodegenerative Disease. CNS Neuroscience & Therapeutics 00 (2011) 1–7.
  4. Kevin Kemp,Elizabeth Mallam, Kelly Hares, Jonathan Witherick, Neil Scolding, and Alastair Wilkins. Mesenchymal Stem Cells Restore Frataxin Expression and Increase Hydrogen Peroxide Scavenging Enzymes in Friedreich Ataxia Fibroblasts.
  5. You-Kang Chang, Ming-Hsiang Chen, Yi-Hung et al. Mesenchymal stem cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cells.