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Autism Male, 17 years old, June 2019

Summary

DiagnosisSexAgeNationality
AutismMale 17 yearsBritish
InjectionsCell typeAdmission dateDischarge date
6UCBSC + UCMSC2019-06-022019-06-16

Condition On Admission

The patient was able to follow verbal commands for easy tasks and needed physical guidance for complex ones. Verbal language was non-existent and the patient was using body language or oral sounds to communicate. He was very sensitive to loud noises and lacked self-awareness. He could not accept that our therapists touch or hold him and would not do any activity with them. In terms of sensory integration, he had tactile oversensitivity in the lower body. For instance he could not put his feet or his knees on different textures. In terms of perception, he could match colors, pick an animal, a color, or a fruit from 2 choices. The concept of numbers was still hard to comprehend for him. Prior to our treatment program, he had been having ABA, OT, speech, PT and play therapy back home.

Treatment Schedule

The patient received 3 umbilical cord blood-derived stem cell (UCBSC) packets and 3 umbilical cord-derived mesenchymal stem cell (UCMSC) packets by intravenous (IV) and intrathecal injections, as per the schedule below.

In addition to stem cell injections, the patient received a daily rehabilitation therapy program that included occupational therapy, aquatic therapy, transcranial magnetic stimulation and fecal microbiota transplant.

NumberDateCell TypeDelivery MethodSide Effects
12019-06-03UCMSCIntravenous Injectionnone reported
22019-06-06UCMSCIntrathecal Injection &
Intravenous Injection
none reported
32019-06-11UCBSCIntrathecal Injection &
Intravenous Injection
none reported
42019-06-14UCBSCIntravenous Injectionnone reported

Condition at discharge

After completing our therapeutic program, the patient’s trust and social abilities improved and he was participating more with the therapists. His sensory integration has improved as well and he has started placing his feet and his knees on a puzzle during activities. Regarding his eating pattern, the patient’s mother reported that he has just started eating new foods, such as rice, crackers, banana, pasta, carrots, and a variety of green vegetables. This shows that his oral tactile sense has gradually improved. Cognition and communication-wise, he could now follow 2 step-commands better (restricted to one easy step command prior to starting the treatment). Finally, the patient started to understand the concept of numbers; He could for instance conclude and answer a question such as “How many?” (limited to numbers from 1 to 5). Sometimes, he imitated the therapist’s voice with very light sounds of numbers and easy words, such as, “one”, “fo”, “fa”, “yeh”.

Condition 3 months after treatment

At the 3 month follow up point the patient’s mother evaluated the improvements made as “moderate”. She thought that the patient’s quality of life had moderately improved and she mentioned: “The improvements have reached their peak and are stable” .

Please see an excerpt from the patient’s mother’s 3 month assessment below:

SymptomParents’ Assessment of Improvement
Anxiety or fearfulnessSmall improvement
Appropriate facial expressionsModerate improvement
Asking questionsSmall improvement
Aware of dangerNo improvement
Aware of environmentSmall improvement
Comfortable with physical contactModerate improvement
ConcentrationModerate improvement
Cooperation with othersModerate improvement
Dressing himself/herselfSignificant improvement
Expressing own needsSmall improvement
Fixation on objects or subjectsSmall improvement
General conversationSmall improvement
General moodSmall improvement
HyperactivitySmall improvement
Interaction with othersModerate improvement
Interest in othersSmall improvement
Limited dietSignificant improvement
Over/under eatingSignificant improvement
Plays appropriatelyModerate improvement
Repetitive movementsSmall improvement
Responding to commandsModerate improvement
Rigidity in routineModerate improvement
Sensitivity to painNo improvement
Showing imaginationModerate improvement
Sleep disturbanceSmall improvement
Understanding storiesNo improvement
Uses eye contactModerate improvement
Uses greetingsModerate improvement
Using more than one word at a timeNo improvement
Using sentencesNo improvement