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Case Study Cerebral Palsy Female, 13 years old, January – February 2012

Summary

Diagnosis Sex Age Nationality
Cerebral Palsy Female 13 years Argentinia
Injections Cell type Admission date Discharge date
8 UCBSC 2012-01-18 2012-02-18

Condition On Admission

The patient had a development delay of movement on the right side of her body since birth. During physical assessment upon her admission to the hospital she was found to be fully alert to her surroundings and her memory and perceptual functions were also normal. The muscle strength, tone, and reflexes of her left sided limbs were normal. Muscle strength of her right limbs was 4/5 and her muscle tone on that side was affected by spasticity. Tendon reflexes on the right side were present.

Treatment Schedule

The patient received 7 umbilical cord blood-derived stem cell (UCBSC) packets by intravenous (IV) and intrathecal injections as per schedule below:

Number Date Cell Type Delivery Method Side Effects
1 2012-01-22 UCBSC Intrathecal Injection &
Intravenous Injection
headache
2 2012-02-01 UCBSC Intravenous Injection none reported
3 2012-02-01 UCBSC Intravenous Injection none reported
4 2012-02-03 UCBSC Intrathecal Injection none reported
5 2012-02-06 UCBSC Intrathecal Injection none reported
6 2012-02-11 UCBSC Intrathecal Injection none reported
7 2012-02-15 UCBSC Intravenous Injection none reported

Condition at discharge

The side effects noticed after the 2nd injection had resolved without any lasting effects by the end of the treatment. The doctors noted the patient’s right arm movement had gained flexibility and her ability to control her trunk muscles had improved. The patient’s parents commented that their daughter had made some good improvements at the hospital and they were hopeful for further developments in the near future.

Condition 6 months after treatment

The patient’s family sent a small update about their daughter stating that she was able to speak with more fluidity and her right side was not as spastic as before the treatment.

Condition 14 months after treatment

The patient’s family, in the 14 months since treatment, had observed big improvements in their daughter’s quality of life and physical condition. Along with the physical improvements reported in the follow-up survey below, the family also mentioned that her intellectual and language abilities had also greatly improved. Please see an excerpt from the patient’s 14 month assessment below (submitted by the patient’s parents):

Symptom Assessment of Improvement
Trunk control Significant improvement
Balance Significant improvement
Movement in general Significant improvement
Walking Significant improvement
Standing up Moderate improvements
Spasticity Significant improvement
Overall strength Significant improvement
Limb muscle strength Significant improvement
Trunk muscle strength Significant improvement
Range of movement Significant improvement
Hand control Significant improvement
Speech Significant improvement
General mental ability Significant improvement