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Case Study Cerebral Palsy Female, 16 months old, Feb – March 2019

Summary

DiagnosisSexAgeNationality
Cerebral PalsyFemale 16 yearsColombia
InjectionsCell typeAdmission dateDischarge date
8UCBSC2019-02-252019-03-18

Medical history

The patient was victim of a cardiorespiratory arrest at 4 months old which caused hypoxic ischemic encephalopathy and left her diagnosed with cerebral palsy. She was affected by one single epileptic seizure at 45 days after her cardiorespiratory arrest and she never had a seizure again after that episode.

Condition On Admission

At admission, the patient had respiratory problems and needed suctioning regularly. She had poor/fair arousal level and impaired vision. She had moderate spasticity in all extremities. She had abnormal reflexes (including abnormal asymmetrical tonic neck reflex). Her development was delayed in all aspects. She could not roll over, crawl, sit, nor stand by herself. She was unable to communicate with others, but was able to cry to show her needs. Prior to starting our stem cell treatment, she regularly had physiotherapy, occupational therapy, speech therapy, hydrotherapy, and Vojta.

Treatment Schedule

The patient received 8 umbilical cord blood-derived stem cell (UCBSC) packets by intravenous (IV) and intrathecal injections, as per the schedule below:

NumberDateCell TypeDelivery MethodSide Effects
12019-03-01UCBSCIntravenous Injectionnone reported
22019-03-05UCBSCIntrathecal Injectionnone reported
32019-03-08UCBSCIntrathecal Injection &
Intravenous Injection
none reported
42019-03-12UCBSCIntrathecal Injection &
Intrathecal Injection
none reported
52019-03-15UCBSCIntrathecal Injection &
Intravenous Injection
none reported

Condition at discharge

The patient’s visual perception has improved as she now responds more to the light coming from a light ball in a dark room setting. She can move her eyes and follow the light source for a few seconds and she can recognize many light colors (initially, she could only recognize a yellow light). There is however still no eye tracking with non lit objects but there is a response when the therapist stimulates the patient with verbal and physical prompts, as she slightly turns her head, raises it up, and smiles. According to her delayed development and visual problems, her gross and fine motor skills need to be continuously stimulated by those rehabilitative programs that she has always been doing. Currently, she is unable to freely turn her head and she can only hold it in a neutral position for a few seconds. Her four limbs are still spastic which limits her movements and prevent normal  pattern. Regarding her hand function, she can grasp and release objects with over-hand support. Sometimes she can release objects independently but improvements in that area are not stable at the moment. The patient needs to keep doing therapies to inhibit her abnormal reflex and hypertonicity along with exercises to stimulate her motor development.

Condition 6 months after treatment

At the 6 month follow up point the patient’s parents reported significant improvements in the patient’s general physical condition and they were mentioning that improvements were continuously being made. They rated the patient’s quality of life improvement as moderate and mentioned: “Her head and trunk control has improved. Her swallowing has also improved, and she recognizes and connects with her environment very well. When she consults with our local specialists, everyone sees improvements and recovery. They say that she has only improved and has not worsened at all.”

Please see an excerpt from the patient’s 6 month assessment below (filled by her parents):

SymptomAssessment of Improvement
AppetiteModerate improvement
BalanceModerate improvement
Bladder controlModerate improvement
CrawlingSmall improvement
DroolingSignificant improvement
Head controlSignificant improvement
Involuntary movementsModerate improvement
Limb muscle strengthSignificant improvement
Mood disorderModerate improvement
Range of movementModerate improvement
SpasticitySignificant improvement
Speech (babbling for infants)Moderate improvement
Standing upModerate improvement
SwallowingSignificant improvement
Trunk muscle strengthModerate improvement
WalkingSmall improvement