Case Study Cerebral Palsy Female, 16 months old, Feb – March 2019


Diagnosis Sex Age Nationality
Cerebral Palsy Female 16 years Colombia
Injections Cell type Admission date Discharge date
8 UCBSC 2019-02-25 2019-03-18

Medical history

The patient was victim of a cardiorespiratory arrest at 4 months old which caused hypoxic ischemic encephalopathy and left her diagnosed with cerebral palsy. She was affected by one single epileptic seizure at 45 days after her cardiorespiratory arrest and she never had a seizure again after that episode.

Condition On Admission

At admission, the patient had respiratory problems and needed suctioning regularly. She had poor/fair arousal level and impaired vision. She had moderate spasticity in all extremities. She had abnormal reflexes (including abnormal asymmetrical tonic neck reflex). Her development was delayed in all aspects. She could not roll over, crawl, sit, nor stand by herself. She was unable to communicate with others, but was able to cry to show her needs. Prior to starting our stem cell treatment, she regularly had physiotherapy, occupational therapy, speech therapy, hydrotherapy, and Vojta.

Treatment Schedule

The patient received 8 umbilical cord blood-derived stem cell (UCBSC) packets by intravenous (IV) and intrathecal injections, as per the schedule below:

Number Date Cell Type Delivery Method Side Effects
1 2019-03-01 UCBSC Intravenous Injection none reported
2 2019-03-05 UCBSC Intrathecal Injection none reported
3 2019-03-08 UCBSC Intrathecal Injection &
Intravenous Injection
none reported
4 2019-03-12 UCBSC Intrathecal Injection &
Intrathecal Injection
none reported
5 2019-03-15 UCBSC Intrathecal Injection &
Intravenous Injection
none reported

Condition at discharge

The patient’s visual perception has improved as she now responds more to the light coming from a light ball in a dark room setting. She can move her eyes and follow the light source for a few seconds and she can recognize many light colors (initially, she could only recognize a yellow light). There is however still no eye tracking with non lit objects but there is a response when the therapist stimulates the patient with verbal and physical prompts, as she slightly turns her head, raises it up, and smiles. According to her delayed development and visual problems, her gross and fine motor skills need to be continuously stimulated by those rehabilitative programs that she has always been doing. Currently, she is unable to freely turn her head and she can only hold it in a neutral position for a few seconds. Her four limbs are still spastic which limits her movements and prevent normal  pattern. Regarding her hand function, she can grasp and release objects with over-hand support. Sometimes she can release objects independently but improvements in that area are not stable at the moment. The patient needs to keep doing therapies to inhibit her abnormal reflex and hypertonicity along with exercises to stimulate her motor development.

Condition 6 months after treatment

At the 6 month follow up point the patient’s parents reported significant improvements in the patient’s general physical condition and they were mentioning that improvements were continuously being made. They rated the patient’s quality of life improvement as moderate and mentioned: “Her head and trunk control has improved. Her swallowing has also improved, and she recognizes and connects with her environment very well. When she consults with our local specialists, everyone sees improvements and recovery. They say that she has only improved and has not worsened at all.” Please see an excerpt from the patient’s 6 month assessment below (filled by her parents):

Symptom Assessment of Improvement
Appetite Moderate improvement
Balance Moderate improvement
Bladder control Moderate improvement
Crawling Small improvement
Drooling Significant improvement
Head control Significant improvement
Involuntary movements Moderate improvement
Limb muscle strength Significant improvement
Mood disorder Moderate improvement
Range of movement Moderate improvement
Spasticity Significant improvement
Speech (babbling for infants) Moderate improvement
Standing up Moderate improvement
Swallowing Significant improvement
Trunk muscle strength Moderate improvement
Walking Small improvement


  1. Intravenous grafts recapitulate the neurorestoration afforded by intracerebrally delivered multipotent adult progenitor cells in neonatal hypoxic-ischemic rats
  2. Umbilical cord blood cells and brain stroke injury: bringing in fresh blood to address an old problem
  3. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains
  4. Human cord blood transplantation in a neonatal rat model of hypoxic-ischemic brain damage: functional outcome related to neuroprotection in the striatum
  5. Li Huang, Che Zhang et al (2018). A Randomized, Placebo-Controlled Trial of Human Umbilical Cord Blood Mesenchymal Stem Cell Infusion for Children With Cerebral Palsy. Cell Transplantation (2018) Vol. 27(2) 325-334
  6. F. Ramirez, ET AL. Umbilical Cord Stem Cell Therapy for Cerebral Palsy. Med Hypotheses RES 2006.3: 679-686.
  7. James E Carroll & Robert W Mays. Update on stem cell therapy for cerebral palsy. Expert Opin. Biol. Ther. (2011) 11.
  8. David T. Harris. Cord Blood Stem Cells: A Review of Potential Neurological Applications. Stem Cell Rev (2008) 4:269–274.