English


Case Study Cerebral Palsy Female, 2 years old, March 2012

Summary

Diagnosis Sex Age Nationality
Cerebral Palsy Female 2 years Argentinia
Injections Cell type Admission date Discharge date
7 UCBSC 2012-03-03 2012-04-01

Condition On Admission

The patient was born with encephalopathy and had speech and movement development delays. The patient could not speak, sit, or walk upon admission to the hospital. She could move her limbs, but without any control. Muscle tone in both arms and legs was high.

Treatment Schedule

The patient received 7 umbilical cord blood-derived stem cell (UCBSC) packets by intravenous (IV) and intrathecal injections as per schedule below:

Number Date Cell Type Delivery Method Side Effects
1 2012-03-05 UCBSC Intravenous Injection none reported
2 2012-03-07 UCBSC Intrathecal Injection none reported
3 2012-03-12 UCBSC Intrathecal Injection none reported
4 2012-03-16 UCBSC Intrathecal Injection none reported
5 2012-03-21 UCBSC Intrathecal Injection none reported
6 2012-03-23 UCBSC Intravenous Injection none reported
7 2012-03-28 UCBSC Intrathecal Injection none reported

Condition at discharge

The patient had no fever, headaches, or other side effects after transplantation of the stem cells. The doctors reported that the spasticity in her limbs had decreased, the movement of her right arm had become more controlled and flexible, and she had better overall body balance.

Condition 3 months after treatment

The patient’s parents completed the follow-up survey three months after the treatment; they commented that their daughter was now much more active and she had shown a big development in her speech. As for physical improvements, they observed that her trunk muscles had gained much more strength and she was now able to remain seated for longer periods. Her balance had also improved to the point where she was now able to stand with some support for longer periods of time. They felt their daughter’s quality of life had improved since the treatment.

Please see the excerpt below from her 3 month follow-up survey (filled out by the patient’s parents):

Symptom Parents’ Assessment of Improvement
Trunk control Significant improvement
Balance Moderate improvement
Movement in general Moderate improvement
Walking Moderate improvement
Overall strength Significant improvement
Limb muscle strength Moderate improvements
Trunk muscle strength Significant improvement
Range of movement Moderate improvements
Fine motor control Moderate improvements
Hand control Moderate improvements
Speech Significant improvement
General mental ability Significant improvement