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Case Study Cerebral Palsy Female, 2 years old, March 2012

Summary

DiagnosisSexAgeNationality
Cerebral PalsyFemale 2 yearsArgentinia
InjectionsCell typeAdmission dateDischarge date
7UCBSC2012-03-032012-04-01

Condition On Admission

The patient was born with encephalopathy and had speech and movement development delays. The patient could not speak, sit, or walk upon admission to the hospital. She could move her limbs, but without any control. Muscle tone in both arms and legs was high.

Treatment Schedule

The patient received 7 umbilical cord blood-derived stem cell (UCBSC) packets by intravenous (IV) and intrathecal injections as per schedule below:

NumberDateCell TypeDelivery MethodSide Effects
12012-03-05UCBSCIntravenous Injectionnone reported
22012-03-07UCBSCIntrathecal Injectionnone reported
32012-03-12UCBSCIntrathecal Injectionnone reported
42012-03-16UCBSCIntrathecal Injectionnone reported
52012-03-21UCBSCIntrathecal Injectionnone reported
62012-03-23UCBSCIntravenous Injectionnone reported
72012-03-28UCBSCIntrathecal Injectionnone reported

Condition at discharge

The patient had no fever, headaches, or other side effects after transplantation of the stem cells. The doctors reported that the spasticity in her limbs had decreased, the movement of her right arm had become more controlled and flexible, and she had better overall body balance.

Condition 3 months after treatment

The patient’s parents completed the follow-up survey three months after the treatment; they commented that their daughter was now much more active and she had shown a big development in her speech. As for physical improvements, they observed that her trunk muscles had gained much more strength and she was now able to remain seated for longer periods. Her balance had also improved to the point where she was now able to stand with some support for longer periods of time. They felt their daughter’s quality of life had improved since the treatment.

Please see the excerpt below from her 3 month follow-up survey (filled out by the patient’s parents):

SymptomParents’ Assessment of Improvement
Trunk controlSignificant improvement
BalanceModerate improvement
Movement in generalModerate improvement
WalkingModerate improvement
Overall strengthSignificant improvement
Limb muscle strengthModerate improvements
Trunk muscle strengthSignificant improvement
Range of movementModerate improvements
Fine motor controlModerate improvements
Hand controlModerate improvements
SpeechSignificant improvement
General mental abilitySignificant improvement