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Case Study Optic Nerve Hypoplasia Female, 16 months old, January – July 2011

Summary

Diagnosis Sex Age Nationality
Optic Nerve Hypoplasia (ONH) / Septooptic Dysplasia (SOD) Female 16 months Irish
Injections Cell type Admission date Discharge date
8 UCMSC 2011-01-16 2011-03-01

Condition On Admission

The patient had bilateral vision deterioration and a development delay since she was 5 months old. On physical examination her eyeballs were normal and pupils were equal and reactive to light. She could recognize light and darkness. Nystagmus was present. She could not look at objects and mostly let her head hang down to the floor when sitting.

Treatment Schedule

The patient received 8 umbilical cord-derived mesenchymal stem cell (UCMSC) packets by intravenous (IV) injections as per the schedule below:

Number Date Cell Type Delivery Method Side Effects
1 2011-01-19 UCMSC Intravenous Injection none reported
2 2011-01-21 UCMSC Intravenous Injection none reported
3 2011-01-24 UCMSC Intravenous Injection none reported
4 2011-01-28 UCMSC Intravenous Injection none reported
5 2011-02-11 UCMSC Intravenous Injection none reported
6 2011-02-16 UCMSC Intravenous Injection none reported
7 2011-02-21 UCMSC Intravenous Injection none reported
8 2011-02-25 UCMSC Intravenous Injection none reported

Condition at discharge

Stem cell treatment was completed without any adverse events or side effects. At the end of the treatment period the patient was able to reach out and grasp objects 50cm in front of her and track light with her eyes. There was also a decrease in the nystagmus.

Condition 1 month after treatment

One month after their daughter’s treatment the parents completed a Beike follow-up survey and in this survey they reported that their daughter had made significant progress in her physical condition and that her quality of life had significantly improved. At the time they also felt that new improvements were still being made by their daughter.

Condition 12 months after treatment

Please see an excerpt from the patient’s 12 month assessment below:

Symptom Parents’ Assessment of Improvement
Blindness Significant improvement
Light perception Significant improvement
Ability to see hand movement Significant improvement
Vision in left eye Significant improvement
Vision in right eye Significant improvement
Night vision Significant improvement
Ability to see things at a close distance Significant improvement
Nystagmus Significant improvement
Strabismus Significant improvement