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Case Study Septo-Optic Dysplasia Female, 2 years old, June – August 2011

Summary

Diagnosis Sex Age Nationality
Optic Nerve Hypoplasia (ONH) / Septooptic Dysplasia (SOD) Female 2 years USA
Injections Cell type Admission date Discharge date
7 UCBSC 2011-06-21 2011-07-11

Condition On Admission

The patient was admitted for treatment for her vision problem. Physical examination showed the movement of her eyeballs was good. Spontaneous nystagmus was present. Her pupils were normal in shape and reactive to light. The patient could differentiate between light and dark. Eye tests could not be conducted due to her young age; therefore it was difficult to confirm her exact visual acuity. The other tests after admission showed no significant abnormalities.

Treatment Schedule

The patient received 7 umbilical cord blood-derived stem cell (UCBSC) packets by intravenous (IV) injections as per schedule below:

Number Date Cell Type Delivery Method Side Effects
1 2011-06-24 UCBSC Intravenous Injection none reported
2 2011-06-27 UCBSC Intravenous Injection &
Intravenous Injection
none reported
3 2011-07-01 UCBSC Intravenous Injection &
Intravenous Injection
none reported
4 2011-07-04 UCBSC Intravenous Injection &
Intravenous Injection
none reported

Condition at discharge

After treatment the doctors noted the patient could track light with her right eye and the frequency of nystagmus had reduced. The family were pleased with the improvements their daughter had gained during the treatment, especially the improvements in her vision. They also reported at the time of discharge that her bowel function had also improved. The patient was now having a daily bowel movement, whereas prior to treatment it was every 2 or 3 days.

Symptom Parents’ Assessment of Improvement
Light perception Moderate improvement
Vision in left eye Small improvement
Vision in right eye Moderate improvement
Ability to see things clearly Small improvement
Ability to focus eyes quickly Small improvement
Ability to keep eyes focused for a long time Moderate improvement
Ability to see things at a far distance Small improvement
Nystagmus (uncontrolled eye movement) Small improvement

Condition 3 months after treatment

The parents completed the Beike follow-up survey three months after the treatment. They were pleased with the improvements the treatment had given their daughter for both her physical condition and quality of life. In addition to the improvements in the symptoms listed below, the parents felt their daughter had more confidence to move around. Below is an excerpt from the parent’s completed 3-month follow-up survey:

Symptom Parents’ Assessment of Improvement
Blindness Moderate improvement
Light perception Moderate improvement
Ability to see hand movement Significant improvement
Able to count fingers Significant improvement
Vision in left eye Significant improvement
Vision in right eye Small improvement
Color Vision Small improvement
Night vision Small improvement
Ability to see things clearly Significant improvement
Ability to focus eyes quickly Significant improvement
Ability to keep eyes focused for a long time Significant improvement
Ability to see things at a close distance Moderate improvement
Ability to see things at a far distance Significant improvement
Nystagmus (uncontrolled eye movement) Significant improvement

Condition 12 months after treatment

The parents also completed a Beike follow-up survey one year after their daughter’s treatment. They were satisfied with the outcome of the treatment and felt their daughter had made significant improvements in her quality of life and had further improved in her overall physical condition. Below is an excerpt from the parent’s completed 1 year follow-up survey:

Symptom Parents’ Assessment of Improvement
Blindness Significant improvement
Light perception Moderate improvement
Ability to see hand movement Moderate improvement
Able to count fingers Significant improvement
Vision in left eye Significant improvement
Vision in right eye Small improvement
Visual field Small improvement
Color Vision Significant improvement
Night vision Small improvement
Ability to see things clearly Moderate improvement
Ability to focus eyes quickly Small improvement
Ability to keep eyes focused for a long time Moderate improvement
Ability to see things at a close distance Moderate improvement
Ability to see things at a far distance Small improvement
Nystagmus (uncontrolled eye movement) Significant improvement