English


Case Study Septo-Optic Dysplasia Female, 2 years old, June – August 2011

Summary

DiagnosisSexAgeNationality
Optic Nerve Hypoplasia (ONH) / Septooptic Dysplasia (SOD)Female 2 yearsUSA
InjectionsCell typeAdmission dateDischarge date
7UCBSC2011-06-212011-07-11

Condition On Admission

The patient was admitted for treatment for her vision problem. Physical examination showed the movement of her eyeballs was good. Spontaneous nystagmus was present. Her pupils were normal in shape and reactive to light. The patient could differentiate between light and dark. Eye tests could not be conducted due to her young age; therefore it was difficult to confirm her exact visual acuity. The other tests after admission showed no significant abnormalities.

Treatment Schedule

The patient received 7 umbilical cord blood-derived stem cell (UCBSC) packets by intravenous (IV) injections as per schedule below:

NumberDateCell TypeDelivery MethodSide Effects
12011-06-24UCBSCIntravenous Injectionnone reported
22011-06-27UCBSCIntravenous Injection &
Intravenous Injection
none reported
32011-07-01UCBSCIntravenous Injection &
Intravenous Injection
none reported
42011-07-04UCBSCIntravenous Injection &
Intravenous Injection
none reported

Condition at discharge

After treatment the doctors noted the patient could track light with her right eye and the frequency of nystagmus had reduced. The family were pleased with the improvements their daughter had gained during the treatment, especially the improvements in her vision. They also reported at the time of discharge that her bowel function had also improved. The patient was now having a daily bowel movement, whereas prior to treatment it was every 2 or 3 days.

SymptomParents’ Assessment of Improvement
Light perceptionModerate improvement
Vision in left eyeSmall improvement
Vision in right eyeModerate improvement
Ability to see things clearlySmall improvement
Ability to focus eyes quicklySmall improvement
Ability to keep eyes focused for a long timeModerate improvement
Ability to see things at a far distanceSmall improvement
Nystagmus (uncontrolled eye movement)Small improvement

Condition 3 months after treatment

The parents completed the Beike follow-up survey three months after the treatment. They were pleased with the improvements the treatment had given their daughter for both her physical condition and quality of life. In addition to the improvements in the symptoms listed below, the parents felt their daughter had more confidence to move around.

Below is an excerpt from the parent’s completed 3-month follow-up survey:

SymptomParents’ Assessment of Improvement
BlindnessModerate improvement
Light perceptionModerate improvement
Ability to see hand movementSignificant improvement
Able to count fingersSignificant improvement
Vision in left eyeSignificant improvement
Vision in right eyeSmall improvement
Color VisionSmall improvement
Night visionSmall improvement
Ability to see things clearlySignificant improvement
Ability to focus eyes quicklySignificant improvement
Ability to keep eyes focused for a long timeSignificant improvement
Ability to see things at a close distanceModerate improvement
Ability to see things at a far distanceSignificant improvement
Nystagmus (uncontrolled eye movement)Significant improvement

Condition 12 months after treatment

The parents also completed a Beike follow-up survey one year after their daughter’s treatment. They were satisfied with the outcome of the treatment and felt their daughter had made significant improvements in her quality of life and had further improved in her overall physical condition.

Below is an excerpt from the parent’s completed 1 year follow-up survey:

SymptomParents’ Assessment of Improvement
BlindnessSignificant improvement
Light perceptionModerate improvement
Ability to see hand movementModerate improvement
Able to count fingersSignificant improvement
Vision in left eyeSignificant improvement
Vision in right eyeSmall improvement
Visual fieldSmall improvement
Color VisionSignificant improvement
Night visionSmall improvement
Ability to see things clearlyModerate improvement
Ability to focus eyes quicklySmall improvement
Ability to keep eyes focused for a long timeModerate improvement
Ability to see things at a close distanceModerate improvement
Ability to see things at a far distanceSmall improvement
Nystagmus (uncontrolled eye movement)Significant improvement