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Cerebral Palsy, Male, 3 years old, March – April 2019

Summary

SexAgeNationality
Male3USA
Admission dateDischarge date
2019-03-312019-04-22

Condition On Admission

The patient was born premature at 31 week gestation. He was a victim of a cerebral hemorrhage in the lateral ventricles, which caused periventricular leukomalacia and left him diagnosed with cerebral palsy. Before stem cell treatment the patient was affected by spastic and dystonic quadriplegia and developmental delay. His GMFCS (Gross Motor Function Classification System) level was 5. he was mostly fed via gastrostomy/feeding tube and could accept very little amounts of food provided orally everyday.

Treatment Schedule

NumberDateCell TypeDelivery MethodSide Effects
12019-04-01UCSBCIVNone
22019-04-04UCMSCIVNone
32019-04-04UCMSCLPNone
42019-04-08UCSBCLPNone
52019-04-11UCSBCLPNone
62019-04-16UCSBCLPNone
72019-04-16UCSBCIVNone
82019-04-19UCSBCLPNone

One week after the end of the treatment the patient’s parents noticed an increase in ability to drop from the sofa to a sitting position and remain in the sitting position, using hands and arms to maintain being upright.

Condition 1 month after treatment

The patient’s parents noticed small improvements and mentioned: “Range of movement: His right arm remains tight but he has shown improvement in his left arm. His hips still remain tight but have shown slight improvement. Walking: Able to propel his gait trainer more quickly and with a slightly larger step pattern. Has not mastered turning.”

Condition 3 months after treatment

The patient’s parents assessed the improvement level as moderate. They mentioned: “The walking information was evaluated with Asa in a gait trainer. Walking with manual assistance has improved slightly. Also Asa has shown significant improvement in bilateral hand use, especially playing ball. The area of greatest gains has been in expressive language. […] Asa is able to participate more in reaching out to catch himself in sitting, especially with his left arm. He is helping to feed himself more. He can use both hands to pick up and throw small ball with another person. His physical therapist assisted in completion of the assessment.”

Condition 6 months after treatment

At the 6 month follow up, the patient’s family mentions that improvements are continually being made. “He is able to maintain sitting on the floor for 5 to 10 minutes at a time and is able to navigate his environment independently by rolling and scooting on his back. He is now able to get himself out of sitting without falling. He is making a greater variety of sounds with his mouth and his vocabulary has increased significantly. He can now speak with one to three word phrases.”

Please see an excerpt from the patient’s 6 month assessment below:

Appetite

Small improvement

Balance

Moderate improvement

Crawling

Small improvement

Head control

Moderate improvement

Learning disability

Moderate improvement

Limb muscle strength

Moderate improvement

Range of Movement

Moderate improvement

Spasticity

Small improvement

Speech

Significant improvement

Standing up

Small improvement

Swallowing

Small improvement

Trunk muscle strength

Moderate improvement

Walking

Small improvement