English


Cerebral Palsy, Male, 3 years, May – June 2019

Summary

Diagnosis Sex Age Nationality
Cerebral Palsy Male 3 years Romania
Injections Cell type Admission date Discharge date
6 UCBSC 2019-05-26 2019-06-16

Medical history

The patient was born at a normal gestational age. His condition was stable and he was discharged from the hospital 2 days after birth. Once back home the patient showed some sign of jaundice and the family went back to the hospital. The doctors diagnosed the patient with low blood sugar which was treated by medication. Four to five months later, the family observed a delayed development and requested a doctor consultation. After examination, the patient was diagnosed with cerebral palsy when he was 7 months old.

The condition left the patient with motor disorder, global development delay, epilepsy, inconsistent visual and auditory behaviour and microcephaly. Brain MRI scan from 2016 reported bilateral parieto-occipital gliosis and delayed myelination.

Condition On Admission

During initial assessment at our facility, it was established that the patient was able to express feelings and make some sounds, but could not speak. Muscle tone in his 4 limbs was fluctuating including in his extremities. His neck control was rated as fair and his trunk control was poor. There was joint instability in his shoulders, elbows, wrists, hips, knees and ankles. The movements in his 4 limbs were poor and the patient was unable to sit, crawl or stand. Bed mobility was impaired and standard daily activities needed maximum assistance.

Treatment Schedule

Patient received 6 umbilical cord blood-derived stem cell (UCBSC) packets by intravenous (IV) injection and intrathecal injection through lumbar puncture (LP), as per the schedule below:

Number Date Cell Type Delivery Method Side Effects
1 2019-05-27 UCBSC Intravenous Injection none reported
2 2019-05-31 UCBSC Intrathecal Injection none reported
3 2019-06-03 UCBSC Intrathecal Injection none reported
4 2019-06-06 UCBSC Intrathecal Injection none reported
5 2019-06-11 UCBSC Intrathecal Injection none reported
6 2019-06-14 UCBSC Intravenous Injection none reported

Condition at discharge

It was noticed that the patient has shown some improvements are as follows:

  • Neck control: He can control his head up in neutral position for 30-40 seconds while sitting and watching videos. He can turn his head to follow a song that he is interested in.
  • Sitting balance: He is able to control his trunk, but his back muscle and abdominal muscles are not strong enough and also he has fluctuated tone of muscles. So, he needs the maximal support. Now, he learns how to move and how to inhibit his tone and also his muscle power of trunk has been slightly increased so that he can sit with lesser support (moderate support).
  • Joint instability: He has shoulder, elbow, wrist, hip, knee and ankle joint instabilities so during transferring or therapy session one must be very careful to not cause joint dislocation. His parents need to protect his joints by keep doing therapy and always being aware of positioning.
  • Hand movements: The patient can grasp and release objects with assistance and when he is cooperating well, he can now grasp and release objects with his right hand with less assistance. For the left hand, he still needs full assistance. Moreover, the patient can now sit independently for 2-3 minutes by using his hands to support himself.

Condition 6 months after treatment

At the 6 month follow up point the patient’s family reported that they were satisfied with the outcome and that the treatment had slightly improved the patient’s  quality of life. Improvements were still progressively being made.

Please see an excerpt from the patient’s 6 month assessment below:

Symptom Parents’ Assessment of Improvement
Appetite Moderate improvement
Balance Small improvement
Drooling Small improvement
Drooling Small improvement
Head Control Moderate improvement
Involuntary movements Small improvement
Limb muscle strength Small improvement
Range of movement Moderate improvement
Spasticity Small improvement
Speech Small improvement
Swallowing Small improvement
Trunk muscle strength Small improvement