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Cerebral Palsy Male, 9 years old, Feb-March 2019

Summary

DiagnosisSexAgeNationality
Cerebral PalsyMale 9 yearsPolish
InjectionsCell typeAdmission dateDischarge date
7UCBSC2019-02-102019-03-03

Medical history

This new-born male baby was born by caesarean section from a complicated pregnancy at 32 weeks of gestation due to fetal bradycardia (low fetal heart rate). At birth, the new-born had symptoms of intermediate degree asphyxia and was later on diagnosed with hemorrhagic hydrocephalus which he was treated for, as well as hypoxic ischemic encephalopathy.

Condition On Admission

The patient could understand commands but was only able to speak single words. He could only move with a lot of assistance and could not walk. He could however sit independently. He had severe spasticity and coordination issues. Concentration was poor.

Treatment Schedule

The patient received 6 umbilical cord blood-derived stem cell (UCBSC) packets by intravenous (IV) and intrathecal injections, as per the schedule below. In addition to stem cell injections, the patient received a daily rehabilitation therapy program that included physiotherapy, aquatic therapy, transcranial magnetic stimulation, acupuncture and hyperbaric oxygen therapy.

NumberDateCell TypeDelivery MethodSide Effects
12019-02-11UCBSCIntravenous Injectionnone reported
22019-02-13UCBSCIntravenous Injectionnone reported
32019-02-15UCBSCIntrathecal Injectionnone reported
42019-02-18UCBSCIntrathecal Injectionnone reported
52019-02-22UCBSCIntrathecal Injectionnone reported
62019-02-25UCBSCIntrathecal Injectionnone reported
72019-03-01UCBSCIntravenous Injectionnone reported

Condition at discharge

The patient has stronger trunk muscles which allow him to better control his whole body when sitting on a therapeutic ball as he can now strongly move his body in different directions with minimal support. The patient has shown improvement in standing balance as well as he can stand longer and in a more stable way. His concentration has improved as he can now focus on an activity from 3 to 5 minutes compared to an attention span of 1 minute initially. Moreover, regarding his hand function, he can now voluntarily open his left hand to grasp and release an object more often.

Condition 6 months after treatment

The patient’s parents mentioned: “He walks better on our balcony, he is using his left hand more often, he can pull himself up. He is more focused and calm as well. He can now combine two words which he couldn’t do before. His doctor observed a significant improvement in his condition.

Condition 12 months after treatment

At the 12 month follow up point the patient’s parents reported: “He moves better, when we hold his hands, he walks better, he can maintain a correct posture”. In addition, please see an excerpt from the patient’s 12 month assessment below (filled by his parents):

SymptomAssessment of Improvement
AppetiteSignificant improvement
BalanceModerate improvement
Bladder controlSignificant improvement
CrawlingSignificant improvement
DroolingSmall improvement
Head controlSignificant improvement
Involuntary movementsModerate improvement
Learning disabilityModerate improvement
Limb muscle strengthSignificant improvement
Mood disorderModerate improvement
Range of movementSignificant improvement
SpasticityModerate improvement
Speech (babbling for infants)Significant improvement
Standing upSignificant improvement
SwallowingSignificant improvement
Trunk muscle strengthModerate improvement
WalkingSignificant improvement