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Optic nerve hypoplasia (ONH), Female, 6 years old, Dec – Jan 2018

Summary

Diagnosis Sex Age Nationality
Optic Nerve Hypoplasia (ONH) / Septooptic Dysplasia (SOD) Female 6 years USA
Injections Cell type Admission date Discharge date
7 UCMSC 2018-12-20 2019-01-04

Condition On Admission

Baylie had learning disability. She had Diabetes Insipidus and autistic behaviors. She did not talk but could understand. She was affected by constipation and lack of sleep. She did not walk and she was totally blind from birth but she gained a little bit of sight overtime.

Treatment Schedule

Patient received 6 umbilical cord blood-derived stem cell (UCBSC) packets by intravenous (IV)
injection and lumbar puncture (LP), as per the schedule below:

Number Date Cell Type Delivery Method Side Effects
1 2018-12-21 UCMSC Intravenous Injection none reported
2 2018-12-25 UCMSC Intrathecal Injection none reported
3 2018-12-25 UCMSC none reported
4 2018-12-28 UCMSC Intravenous Injection none reported
5 2018-12-28 UCMSC none reported
6 2020-01-02 UCMSC Intrathecal Injection none reported
7 UCMSC Intravenous Injection None

Condition 6 months after treatment

Condition 6 months after treatment: At the 6 month follow up point, Baylie’s family mentioned: “Baylie can now see up to about 2 to 3 feet. She is starting to focus on things and look at them instead of feeling for them. Amazing improvement. Baylie has muscle tone improvement. She is definitely more active and her posture is way better.”

Please see an excerpt from the family’s 6 month assessment below:

Symptom Parents’ Assessment of Improvement
Ability to focus eyes quickly Moderate improvement
Ability to keep eyes focused for a long time Small improvement
Ability to see hand movement Significant improvement
Ability to see things at a close distance Significant improvement
Ability to see things at a far distance Moderate improvements
Ability to see things clearly Moderate improvements
Able to count fingers Significant improvement
Blindness Significant improvement
Colour vision Significant improvement
Light perception Significant improvement
Night vision Moderate improvements
Nystagmus Moderate improvements
Strabismus Small improvement
Vision in left eye Significant improvement
Vision in right eye Significant improvement
Visual field Significant improvement