English


Spinal Cord Injury Male, 48 years old, July – August 2018

Summary

DiagnosisSexAgeNationality
Spinal Cord InjuryMale 48 yearsAustralian
InjectionsCell typeAdmission dateDischarge date
6UCBSC + UCMSC2018-07-232018-08-16

Medical history

The patient was diagnosed with spinal cord injury in 2016 from lifting heavy objects (over 15-20 kg). He had severe lower back pain that caused pain in both legs as well. In may 2016, an MRI scan test result revealed severe central canal and neuroforaminal stenosis at the L4-L5 level due to broad-based disc bulge. As a result, the patient had a laminectomy surgery in L3-L5 and a microdiscectomy surgery in L4-L5 as well as a postoperative rehabilitation program for pain relief.

Condition On Admission

The patient had numbness in both legs with the left leg being more affected. There was muscle weakness in the left leg as well. Dynamic standing balance was rated as fair, muscle endurance was low and there was partial bowel and bladder function impairment. The patient was able to engage in all daily activities, independently.

Treatment Schedule

The patient received 3 umbilical cord blood-derived stem cell (UCBSC) packets and 3 umbilical cord mesenchymal stem cell (UCMSC) packets by intravenous (IV) and intrathecal injections, as per the schedule below:

NumberDateCell TypeDelivery MethodSide Effects
12018-07-27UCMSCIntravenous Injectionnone reported
22018-07-31UCMSCIntrathecal Injectionnone reported
32018-08-03UCMSCIntrathecal Injectionnone reported
42018-08-06UCBSCIntrathecal Injectionnone reported
52018-08-10UCBSCIntrathecal Injectionnone reported
62018-08-14UCBSCIntravenous Injectionnone reported

Condition at discharge

At the end of the 3 weeks therapeutic program, the patient has shown some improvement in sensation, muscle endurance and dynamic standing balance as follows:

The patient has informed us that he has more feeling in his left leg and his right leg feels now normal. Endurance has slightly improved as he is now capable of walking on the treadmill for 15 minutes with a speed up to 5.5 (compared to less than 10 minutes at a slower speed earlier). Dynamic standing balance went from fair/good, to good/normal. By the end of the program the patient could perform one leg standing for 1 minute without support in aquatic therapy.

Condition 12 months after treatment

At the 12 month follow up point the patient reported that he still had numbness in a small area behind the left leg with a little pain but he was feeling better than before the treatment. He rated his improvement in quality of life as moderate.

Please see an excerpt from the patient’s 12 month own assessment below:

SymptomAssessment of Improvement
Bladder controlModerate improvement
Bowel controlModerate improvement
Control of body temperatureSignificant improvement
FatigueSignificant improvement
Fine motor controlModerate improvement
Lower limb muscle toneSignificant improvement
Lower limb sensationModerate improvement
Lower limb strengthModerate improvement
PainModerate improvement
Sexual FunctionModerate improvement
Skin ConditionSignificant improvement
SweatingSignificant improvement
Trunk muscle strengthModerate improvement
Trunk muscle toneSignificant improvement
Trunk sensationModerate improvement
Upper limb muscle toneSignificant improvement
Upper limb sensationSignificant improvement
Upper limb strengthModerate improvement