English


Spinal Cord Injury Male, 48 years old, July – August 2018

Summary

Diagnosis Sex Age Nationality
Spinal Cord Injury Male 48 years Australian
Injections Cell type Admission date Discharge date
6 UCBSC + UCMSC 2018-07-23 2018-08-16

Medical history

The patient was diagnosed with spinal cord injury in 2016 from lifting heavy objects (over 15-20 kg). He had severe lower back pain that caused pain in both legs as well. In may 2016, an MRI scan test result revealed severe central canal and neuroforaminal stenosis at the L4-L5 level due to broad-based disc bulge. As a result, the patient had a laminectomy surgery in L3-L5 and a microdiscectomy surgery in L4-L5 as well as a postoperative rehabilitation program for pain relief.

Condition On Admission

The patient had numbness in both legs with the left leg being more affected. There was muscle weakness in the left leg as well. Dynamic standing balance was rated as fair, muscle endurance was low and there was partial bowel and bladder function impairment. The patient was able to engage in all daily activities, independently.

Treatment Schedule

The patient received 3 umbilical cord blood-derived stem cell (UCBSC) packets and 3 umbilical cord mesenchymal stem cell (UCMSC) packets by intravenous (IV) and intrathecal injections, as per the schedule below:

Number Date Cell Type Delivery Method Side Effects
1 2018-07-27 UCMSC Intravenous Injection none reported
2 2018-07-31 UCMSC Intrathecal Injection none reported
3 2018-08-03 UCMSC Intrathecal Injection none reported
4 2018-08-06 UCBSC Intrathecal Injection none reported
5 2018-08-10 UCBSC Intrathecal Injection none reported
6 2018-08-14 UCBSC Intravenous Injection none reported

Condition at discharge

At the end of the 3 weeks therapeutic program, the patient has shown some improvement in sensation, muscle endurance and dynamic standing balance as follows: The patient has informed us that he has more feeling in his left leg and his right leg feels now normal. Endurance has slightly improved as he is now capable of walking on the treadmill for 15 minutes with a speed up to 5.5 (compared to less than 10 minutes at a slower speed earlier). Dynamic standing balance went from fair/good, to good/normal. By the end of the program the patient could perform one leg standing for 1 minute without support in aquatic therapy.

Condition 12 months after treatment

At the 12 month follow up point the patient reported that he still had numbness in a small area behind the left leg with a little pain but he was feeling better than before the treatment. He rated his improvement in quality of life as moderate. Please see an excerpt from the patient’s 12 month own assessment below:

Symptom Assessment of Improvement
Bladder control Moderate improvement
Bowel control Moderate improvement
Control of body temperature Significant improvement
Fatigue Significant improvement
Fine motor control Moderate improvement
Lower limb muscle tone Significant improvement
Lower limb sensation Moderate improvement
Lower limb strength Moderate improvement
Pain Moderate improvement
Sexual Function Moderate improvement
Skin Condition Significant improvement
Sweating Significant improvement
Trunk muscle strength Moderate improvement
Trunk muscle tone Significant improvement
Trunk sensation Moderate improvement
Upper limb muscle tone Significant improvement
Upper limb sensation Significant improvement
Upper limb strength Moderate improvement