Summary
| Diagnosis | Sex | Age | Nationality |
|---|---|---|---|
| Traumatic Brain Injury | Female | 46 years | Brazil |
| Injections | Cell type | Admission date | Discharge date |
| 7 | UCBSC | 2018-07-09 | 2018-08-02 |
Condition On Admission
The patient’s chief complaint was of weakness in all four limbs for more than 20 years. Patient first noted he had a weakness in both his upper limbs in 1987, which was especially evident in his handwriting. The weakness progressively got worse over time. In 1994, he noticed he had problems walking up and down stairs and would trip over himself from time to time; an MRI confirmed a diagnosis of Ataxia. On physical assessment upon hospital admission he was found to have low muscle tone in all limbs with muscle power of 5/5. Coordination tests such as finger-to-nose and heel-to-tibia showed poor coordination and the patient was unable to walk heel-to-toe. Routine examination showed no other abnormalities.
Treatment Schedule
Patient received 6 umbilical cord blood-derived stem cell (UCBSC) packets by intravenous (IV) injection and lumbar puncture (LP), as per the schedule below:
| Number | Date | Cell Type | Delivery Method | Side Effects |
|---|---|---|---|---|
| 1 | 2018-07-13 | UCBSC | Intravenous Injection | none reported |
| 2 | 2018-07-17 | UCBSC | Intrathecal Injection | none reported |
| 3 | 2018-07-20 | UCBSC | Intrathecal Injection | none reported |
| 4 | 2018-07-23 | UCBSC | Intrathecal Injection | none reported |
| 5 | 2018-07-27 | UCBSC | Intrathecal Injection | none reported |
| 6 | 2018-07-31 | UCBSC | Intrathecal Injection & Intravenous Injection | none reported |
Condition 1 month after treatment
Condition 1 months after treatment: The patient reported significant improvements at one month after his treatment. He stated, “[I] can walk heel to toe, can do the balancing exercise for longer periods of time, can go up and down stairs with no hands.” He also made comments about the importance of continuing to do daily exercise and how it is becoming easier but also feels that the exercises are essential to aiding his continued improvements.
Condition 12 months after treatment
Condition 12 months after treatment: At the 12 month follow up point the patient reported that he was satisfied with the outcome of his treatment which has improved his quality of life and given him moderate improvements overall in his physical condition.
Symptom | Parents’ Assessment of Improvement |
Balance | Moderate improvements |
Coordination | Moderate improvements |
Fine hand movements | Small improvements |
Tremors | Not applicable |
Control of movement | Moderate improvements |
Muscle stiffness | Not applicable |
Speech | Moderate improvements |
Walking | Moderate improvements |
Fatigue | Small improvements |
