Stem Cell Delivery Methods

Providing the Stem Cells Safely and Effectively


The doctors in our affiliated hospitals use various injection methods to deliver stem cells. Depending on each patient specific condition, one or multiple methods of delivery will be used during a standard treatment session in order to maximize safety and efficacy. It is important to remember that Beike Biotechnology's protocols always prioritize safety first and the injections methods provided are little invasive but still a very focused on delivering the stem cells as close as possible from the injury site. For more information regarding the different injection methods please see below.

Intravenous Injection

Intravenous injection

The intravenous injection (IV) can be defined as the infusion of liquid substances directly into a vein. IVs allow healthcare professionals to administer fluids, blood products, and medications directly into a patient’s bloodstream via a small tube. This allows rapid absorption and precise control over the dosage of the substance administered, which is vital for a variety of medical procedures. As stem cells can be taken by the circulatory system to every part of the body, they will migrate to the site of injury or disease.

Infusion Steps:

  1. The IV tubing is being set up properly and two IV bags (saline solution and stem cells) are being suspended on an elevated stand.
  2. The injection site (where the IV will be inserted) is being disinfected.
  3. The IV catheter (IV catheters are mounted over the needle used to puncture the vein) is removed from its sterile packaging and the needle is then inserted into the vein.
  4. The protective cover is being removed from the end of the IV tubing and is carefully inserted into the catheter hub. A piece of tape is placed over the catheter hub to secure the IV.
  5. The nurse checks on the flow of fluid into the vein during the whole procedure which lasts 30 to 60 minutes. If the patient feels any discomfort during or after the procedure, the medical staff on site should be informed immediately.
  6. Once the infusion is done. The nurse closes the roller clamp to stop the flow of fluid. She places a clean piece of gauze over the IV site and applies delicate pressure as the catheter is pulled out.
  7. Patients are asked to press sterile cotton wool onto injection site for at least 5 minutes.

Retrobulbar Injection

Retrobulbar Injection

Retrobulbar injections (RB) are usually used worldwide to provide local anesthesia in the retrobulbar area (behind the eye). During Beike Biotech stem cell treatment protocol, this type of injection is utilized to deliver stem cells as close as possible from the optic nerve and/or retina in order to better target the site of injury.

Infusion Steps:

The whole procedure is quick and safe (as described below) and usually allows our patients to get more benefits from the treatment. Please note that retrobulbar injections will only be provided to patients older than 11 years old. The final decision will be made by the attending doctor upon admission at the hospital.

  1. The patient is asked to lie down. A disinfectant is then carefully applied on the skin from the lower eyelid margin to the lower orbital rim, respectively.
  2. The patient is asked to look toward the opposite side of the eye being treated and look slightly up. If the injection is done for the right eye, the patient should look at the top left and vice versa.
  3. A thin needle is then be inserted vertically about 2 millimeters deep in the quadrant between the outside 1/3 and inside 2/3 of the lower orbital rim.
  4. The needle passes the equator of the eye globe and is then directed towards the upper nasal site until it is about 3 centimeters in depth. Stem cells are then be injected into the the retrobulbar space.
  5. Once the injection is done, the needle is gently removed and the ocular globe is intermittently compressed with disinfected bandages for several minutes. Normally, the entire procedure is completed in about 15 minutes and the injection itself is done in few seconds.

Intrathecal Injection

Lumbar Puncture

The Intrathecal Administration consist of an injection made into the spinal canal in order to access the cerebrospinal fluid (CSF) and by extension, the central nervous system. This type of administration allows to deliver the stem cells to the brain and spinal cord in an easier and more effective way.

Prior injection, a lumbar puncture (LP) is performed in the first place in order to extract a little quantity of CSF and replace it by the stem cells.

Infusion Steps:

  1. The patient is asked to not eat after 10 PM the day before the procedure.
  2. Patients will be moved into a surgical operating suite where the doctor assisted by two nurses, will provide the injection.
  3. Patients will be placed on their side with their backs near the edge of the table or bed. A nurse will then assist patients in bending their knees towards their abdomen and flexing their head to the chest in a fetal position. This position helps to separate the vertebrae so that the needle can be inserted more easily.
  4. The doctor will first examine the patient’s lower back and mark the proper insertion site (between two lumbar vertebrae from L2 to L5).
  5. The area is then cleaned with an antiseptic and a local anesthetic is injected under the skin to numb the area where the needle will be inserted into the spinal canal.
  6. Once the needle is in the correct position, the stylet from spinal needle is then withdrawn and around 2 ml of cerebral spinal fluid is collected.
  7. The stem cells (around 1ml) and saline solution (around 1 ml) will then be administered respectively through the needle into the cerebral spinal fluid.
  8. The procedure is ended by withdrawing the needle with the reinserted stylet while placing pressure on the puncture site. Placement of the needle, along with the infusion, is typically completed in 20 minutes to  hour.
  9. All patients are asked to lie flat for 4 to 6 hours after the procedure to avoid temporary side effects such as headaches, nausea, fevers, vomiting and/or pains in the legs. These symptoms are believed to be a result of the change in fluid volume within the spinal canal. Even lying flat, some patients might still develop these discomforts. These might last for up to 48 hours. Patients should alert the doctors if they have a very severe headache, stiff neck, loss of sensation below the puncture area, or any leakage from the injection area.

Intramuscular Injection

Intramuscular Injection

An intramuscular (IM) injection is a shot of medicine given into a muscle. Intramuscular injections of stem cells can assist patients with muscular dystrophy to receive better health gains. These injections are made directly into the muscles of the affected areas. Upon admission, the doctors will examine the patient and decide how many stem cell packets should be injected locally into the affected muscles. The delivery method has also been applied to treat lower limb ischemia and diabetic foot.

Infusion steps:

  1. The patient is asked to take the appropriate posture to access the affected muscles easily.
  2. The injection site is disinfected. Stem cells are aspirated by a syringe (There are 3 parts of a syringe: the needle to go into the muscle, the barrel to hold the medicine, the plunger to get medicine into and out of the syringe).
  3. The nurse gently presses on and pulls the skin around the injection site so that it is slightly tight. The needle is inserted in the affected muscle and the stem cells are injected slowly.
  4. Once the injection completes, the injection site is pressed with dry cotton and the needle is pulled out rapidly at the same time. A piece of gauze is then placed at the injection site.

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