It is important to remember that improvements experienced by patients diagnosed with hereditary ataxias may not be permanent, as stem cell treatments do not currently have any influence on the genetic origin of these specific types of ataxia. In such cases, periodic treatments may be required to keep a stable condition. Finally, as for any medical treatment, improvements cannot be guaranteed.
Stem Cell Quality and Quantity Ensured
Different types of stem cells for different needs
Beike provides stem cells from two separate sources: umbilical cord blood and umbilical cord tissue. Umbilical cord related samples are donated by healthy mothers after normal births and are sent to Beike Biotech's laboratories for processing.
After reviewing the patient’s full medical information, our doctors will recommend which source of stem cells should be used for treatment. Our treatment protocols may include one or multiple types of stem cell in combination depending on each patient's specific condition.
Highest International Stem Cell Processing Standards
Beike Biotechnology is processing its own adult stem cells in its internationally accredited laboratories. The company has full control over the processing and quality control of all stem cell products, ensuring perfect safety and highest quality. Processing methods and facility are accredited by the American Association of Blood Banks (AABB), the highest international standard in the industry.
Below are video interviews recorded during treatment with Beike stem cells. The families showcased in these videos talk about their personal stories and their experience of the treatment including the improvement noticed. The improvements mentioned in these videos are typical, however it does not guarantee that all patients may have the same improvements.
Extensiveness: A complete supportive therapy program is provided daily to stimulate patient's freshly transplanted stem cells. The best improvement can only be obtain by supporting your stem cells.
Support: A full follow-up program is provided after the treatment and you will be asked to take part in it at 1, 3, 6 and 12 months after treatment. Access to our team after the treatment is very important as you may receive further advice to maximize improvements.
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Founded in July 2005, Shenzhen Beike Biotechnology Co. Ltd. (hereinafter referred to as Beike Biotechnology) is a national high-tech enterprise specialized in clinical transformation and technical service of biological treatment technology of strategic emerging industries.
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More About Ataxia
What is ataxia?
Ataxia is defined as an inability to maintain normal posture and stability of movements. It is a sign and symptom of a central nervous system abnormality instead. The underlying neurological abnormality, which results in ataxia, can be either acquired or hereditary. Hereditary ataxias are a heterogeneous group of neurodegenerative disorders, characterized by degenerative atrophy of the cerebellum, brainstem and/or spinal cord. Spinocerebellar ataxia (SCA) and Friedreich's ataxia (FRDA) are the most common forms of hereditary ataxia.
What causes ataxia?
Most often ataxia is caused by loss of function in the cerebellum, which is the part of the brain that serves as the coordination center. The cerebellum is located toward the lower posterior part of the brain. The right side of the cerebellum controls coordination on the right side of the body while the left side controls coordination in the left part of the body. The central part of the cerebellum controls the very complex movements of gait or walking, head and trunk stability and eye movements. Other parts of the cerebellum help to coordinate eye movements, speech and swallowing.
Ataxia may also be caused by dysfunction of the pathways leading into and out of the cerebellum. Information comes into the cerebellum from the spinal cord, and other parts of the brain and signals from the cerebellum go out to the spinal cord and to the brain. Although the cerebellum does not directly control strength, (motor function) or feeling, (sensory function) the motor sensory pathways must work properly to provide the correct input into the cerebellum. Thus, a person with impaired strength or sensation may notice clumsiness or poor coordination and may be diagnosed with ataxia.
There are many causes that could affect the function of cerebellum. These causes could be classified into 10 categories: developmental (e.g. cerebellar hypoplasia); hereditary (e.g. Friedreich ataxia); vascular (e.g. cerebellar hemorrhage); toxin-associated (e.g. alcohol); medication-associated (e.g. anticonvulsants); neoplastic (e.g. cerebellar tumor); infectious (e.g. encephalitic bacterial infection); immune-associated (e.g. multiple sclerosis); metabolic and nutritional (e.g. deficiency in vitamin E).
How does ataxia affect the patient?
The disease is characterized by progressively disabling clinical manifestations. Patients show symptoms of gait instability or dysarthria and may begin to fall without warning. Gradually they present progressive limitations in their activities, lose the ability to walk, become bedridden and fully dependent. Other clinical manifestations include astasia, impaired fine motor skills and intention tremor (cerebellar tremor). The cerebellar syndrome is often associated with other neurological signs such as pyramidal or extrapyramidal signs, ophthalmoplegia, and cognitive impairment.
How to diagnose ataxia?
Most people don’t know what ataxia is and may overlook the early symptoms. Anyone with progressive gait disorder or imbalance should be evaluated by a neurologist. MRI is recommended in all cases. If a treatable cause is not discovered, a gene test should be done. In about 60 percent of the cases, the gene test will determine the type of ataxia.
What is the efficacy of conventional treatments?
Until now, conventional treatments are generally used to alleviate the symptoms, not the disease itself. The movement disorders can be managed using pharmacological, physical and occupational therapies to minimize the damage and to promote the mobility as long as possible but overall current treatment remains retardant.
What are the difference between autosomal dominant and autosomal recessive ataxias?
Autosomal dominant and autosomal recessive ataxias are hereditary ataxias, and spinocerebellar ataxia (SCA) and Friedreich's ataxia (FRDA) are the most common forms of hereditary ataxia. Autosomal dominant genes express themselves when present. Autosomal recessive genes will only express themselves when in the homozygous state -- i.e., both genes in the gene pair are the recessive gene form. Thus, recessive genes can be "carried" by those whose phenotype does not exhibit the gene characteristic, while dominant genes cannot be "carried". Therefore, generally autosomal dominant ataxias are easier to express and at a higher morbidity than autosomal recessive ataxias.
What is the role of Purkinje cells, where can we find those cells ?
Purkinje cells are a type of neuron found in the cerebellar cortex, at the base of the brain. They are among the largest neurons and are responsible for most of the electrochemical signaling in the cerebellum. The Purkinje cells and the cerebellum are essential to the body's motor function. Disorders involving the Purkinje cells usually negatively affect the patient's movements.