Stem Cell Treatment
for ONH-SOD

Restoring Optic Nerve Function
Using Stem Cells

Optic nerve hypoplasia (ONH) occurs from the underdevelopment of the optic nerve, which carries neuronal transmission from the retina in the eye to the brain1. Septo-optic dysplasia (SOD) – also known as de Morsier syndrome – is a subtype of ONH and results from underdevelopment of the optic nerve, pituitary gland dysfunction, and absence of the septum pellucidum, which is a midline area of the brain. SOD arises from defects during the embryological development of infants and studies show that ONH maybe be related to gene defects as well as embryo exposure to infections.

In addition to the lack of vision which a characteristic symptom of ONH, SOD also triggers other symptoms such as pituitary deficiency, autistic behaviors, epileptic seizures and more.

Few conventional treatment options are available for patients diagnosed with ONH-SOD, which mostly focus on helping the patients to cope with their disability. However, none of them are actually treating the loss of optic nerve function. Stem cells have the ability to regenerate nerve cells in the optic nerve, allowing ONH-SOD patients to gain some vision.

Why our Stem Cell Treatment is Effective

Since 2007, we have been developing comprehensive stem cell treatment protocols for Optic Nerve Hypoplasia (ONH) and Septo-Optic Dysplasia (SOD) to overcome the limitations of conventional therapies. In our protocols, stem cells are combined with specialized therapies for ONH-SOD that not only focus on helping the patient to cope with their symptoms, but also treat the root cause of the condition by promoting the healing of the optic nerve and other affected brain structures. We believe that our comprehensive treatment approach for ONH-SOD gives our patients the best chances for vision improvement, allowing for a better quality of life.

Katelyn's Stem Cell Journey

When she was 3 years old Katelyn traveled to Thailand with her parents in order to get stem cell treatment for her SOD. After her first treatment she started to see light and recognize colors. This video was recorded during her second stem cell treatment in Thailand as her parents hope for even more improvements.

Click here for more videos

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What improvements from our treatment?

What improvements can be obtained from our treatment?

The purpose of our stem cell treatment is to restore neurological function in the brain/spinal cord lesion area, thus, various kinds of improvement are possible after our treatment and our past patients have experienced the following*:

  • Sharpened visual acuity
  • Enhanced light perception
  • Enlarged visual field
  • Brighter night vision
  • Reduced nystagmus
  • Improved strabismus
  • Improved hormonal deficiencies
  • Decreased autistic symptoms

It is important to remember that as for any medical treatment, improvements cannot be guaranteed. Please contact us for more information regarding the possible improvements for a particular case.

Patient Stories

Blogs

Find out more about patients previously treated with Beike stem cell protocols. The families participating in these blog posts talk about their stories and present their own view of the treatment, including thoughts regarding the daily therapies, the stem cell injection themselves as well as improvement noticed during and after treatment.

More Patient Stories

Our Treatment Program in Details

Beike is unlike any other stem cell treatment provider in the world, the reason? Since 2005, we have been developing and optimizing our stem cell treatment protocols with the concept that only a very comprehensive solution can allow our patients to truly benefit from stem cells. We believe that stimulation through various therapies is necessary to enhance stem cell regenerative response, therefore our protocols include daily therapies to support the stem cells. Finally, we provide a wide variety and large quantities of stem cells in order to adapt to each patient specific condition and deliver maximized regenerative potential. Learn more about all the particularities that make our treatment truly comprehensive and unique.

16 to 20 Days Stay

IV, Intrathecal & Retrobulbar Injections

UCBSC / UCMSC Cells

Daily Therapy Program

120-400 Million Cells

Nutrition Program

The Stem Cell Therapy

Stem Cell Therapy

Our stem cell transplantation program for ONH-SOD consist in 6 to 8 simple and minimally invasive injections of umbilical cord derived stem cells. The stem cells are transplanted using two separate methods: by intravenous way using a standard IV drip system, and through intrathecal injection performed after lumbar puncture. Patients older than 10 years old may also receive two retrobulbar injections to better target the optic nerves. Together, these 3 delivery methods allow for increased efficacy while ensuring safety and minimum inconvenience for the patient. Read more about each procedure below:

Intravenous Injection (IV) >    Intrathecal Injection (LP) >    Retrobulbar Injection (RBI) >

Acupuncture

Acupuncture

Acupuncture is a technique in which practitioners stimulate specific points on the body – most often by inserting thin needles through the skin. It is one of the most effective practices used in traditional Chinese medicine. Acupuncture stimulates nerve fibers to transmit signals to the spinal cord and brain, activating the body’s central nervous system. The spinal cord and brain then release hormones responsible for making us feel less pain while improving overall health. Acupuncture may also: increase blood circulation and body temperature, affect white blood cell activity (responsible for our immune function), reduce cholesterol and triglyceride levels, and regulate blood sugar levels.

Aquatherapy

Aquatherapy

Aquatic Physical Therapy is the practice of physical therapy in a specifically designed water pool with a therapist. The unique properties of the aquatic environment enhance interventions for patients with neurological or musculoskeletal conditions. Aquatic therapy includes a wide range of techniques allowing patients to improve their balance, muscle strength and body mechanics. Aquatic therapy works to enhance the rehabilitation process and support effectiveness of stem cell treatment.

Hyperbaric Oxygen Therapy

Hyperbaric Oxygen Therapy

Hyperbaric Oxygen Therapy (HBOT) is the medical use of oxygen at a level higher than atmospheric pressure. The equipment required consists of pressure chamber, which may be of rigid or flexible construction, and a means of delivering 100% oxygen into the respiratory system. Published research shows that HBOT increases the lifespan of stem cells after injection and provides an oxygen-rich atmosphere for the body to function at optimum levels.

Nutrition Therapy

Nutrition Therapy

Medical nutrition therapy (MNT) is a therapeutic approach to treat medical conditions and their associated symptoms via the use of a specifically tailored diet devised and monitored by a specialist. The therapy aims at fixing nutritional deficiencies and physiological imbalances in order to provide the best environment possible for the stem cells to develop properly as well as improving patient’s general health.

Nutritional healthy plate of food

Transcranial Magnetic Stimulation

Transcranial Magnetic Stimulation

Research has shown that TMS can effectively treat symptoms of depression, anxiety, neurological pain, stroke, spinal cord injuries, autism and more. This procedure is very simple and noninvasive. During the procedure, a magnetic field generator or “coil” is placed near the head of the person receiving the treatment. The coil produces small electrical currents in the region of the brain just under the coil via electromagnetic induction. This electrical field causes a change in the transmembrane current of the neuron which leads to depolarization or hyperpolarization of the neuron and the firing of an action potential.

Occupational Therapy

Occupational Therapy

Occupational therapy interventions focus on adapting the environment, modifying the task and teaching the skill, in order to increase participation in and performance of daily activities, particularly those that are meaningful to the patient with physical, mental, or cognitive disorders. Our Occupational Therapists also focus much of their work on identifying and eliminating environmental barriers to independence and participation in daily activities, similar to everyday life.

Physiotherapy

Physiotherapy

Physical therapy or physiotherapy (often abbreviated to PT) is a physical medicine and rehabilitation specialty that, by using mechanical force and movements, remediates impairments and promotes mobility, function, and quality of life through examination, diagnosis, prognosis, and physical intervention. We combine our PT with stem cells for maximum physical rehabilitation improvements.

Nerve Growth Factor (NGF)

Nerve Growth Factor (NGF)

Nerve growth factor (NGF) is a member of the neurotrophic factor (neurotrophin, NTFS) family, which can prevent the death of nerve cells and has many features of typical neurotransmitter molecules. NGF plays an important role in the development and growth of nerve cells. NGF is synthesized and secreted by tissues (corneal epithelial, endothelial, and corneal stromal cells), and it can be up-taken by sympathetic or sensory nerve endings and then transported to be stored in neuronal cell bodies where it can promote the growth and differentiation of nerve cells.

NGF can exert neurotrophic effects on injured nerves and promote neurogenesis (the process of generating neurons from stem cells) that is closely related to the development and functional maintenance and repair of the central nervous system. It is also capable of promoting the regeneration of injured neurons in the peripheral nervous system, improving the pathology of neurons and protecting the nerves against hypoxia (lack of oxygen)/ischemia (lack of blood supply).

Stem Cell Quality and Quantity Ensured

Packaging for Beike Biotechnology Stem Cell products

Different types of stem cells for different needs

Beike provides stem cells from two separate sources: umbilical cord blood and umbilical cord tissue. Umbilical cord related samples are donated by healthy mothers after normal births and are sent to Beike Biotech's laboratories for processing.
After reviewing the patient’s full medical information, our doctors will recommend which source of stem cells should be used for treatment. Our treatment protocols may include one or multiple types of stem cell in combination depending on each patient's specific condition.

Highest International Stem Cell Processing Standards

Beike Biotechnology is processing its own adult stem cells in its internationally accredited laboratories. The company has full control over the processing and quality control of all stem cell products, ensuring perfect safety and highest quality. Processing methods and facility are accredited by the American Association of Blood Banks (AABB), the highest international standard in the industry.

American Association of Blood Banks AABB accreditation logo

Patient Videos

Below are video interviews recorded during treatment with Beike stem cells. The families showcased in these videos talk about their personal stories and their experience of the treatment including the improvement noticed. The improvements mentioned in these videos are typical, however it does not guarantee that all patients may have the same improvements.

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Why Choose Beike?

Why Choose Beike?

Experience: With more than a decade of practice, you are ensured to be advised and treated by competent professionals.

Safety: Accredited by the American Association of Blood Banks (AABB) and following highest international standards, our stem cell processing methods and laboratories ensure that you receive the best stem cell quality available.

Diversity: Multiple types of stem cells having different capabilities are available to adapt to each patient's specific condition. We do not use the same type of stem cells for all patients.

Extensiveness: A complete supportive therapy program is provided daily to stimulate patient's freshly transplanted stem cells. The best improvement can only be obtain by supporting your stem cells.

Support: A full follow-up program is provided after the treatment and you will be asked to take part in it at 1, 3, 6 and 12 months after treatment. Access to our team after the treatment is very important as you may receive further advice to maximize improvements.

Beike Biotechnology head office building located in Shenzhen China

Learn More About Us

Founded in July 2005, Shenzhen Beike Biotechnology Co. Ltd. (hereinafter referred to as Beike Biotechnology) is a national high-tech enterprise specialized in clinical transformation and technical service of biological treatment technology of strategic emerging industries.

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More About ONH-SOD

What is optic nerve hypoplasia (ONH) and septo-optic dysplasia (SOD)?

Optic nerve hypoplasia (ONH) occurs from the underdevelopment of the optic nerve, which carries neuronal transmission from the retina in the eye to the brain1. It is the leading cause of congenital blindness and occurs in approximately 10 in every 100,000 live births. The condition was first described in 1915.
Septo-optic dysplasia (SOD) – also known as de Morsier syndrome – is a subtype of ONH and results from underdevelopment of the optic nerve, pituitary gland dysfunction, and absence of the septum pellucidum, which is a midline area of the brain. SOD arises from defects during the embryological development of infants.

What causes ONH and SOD?

There are numerous causes of ONH, with most cases arising from genetic abnormalities in patients. Mutations in a variety of genes, including the following, result in hypoplasia of the optic nerve: NR2F1, OTX2, VAX1, ATOH7.

In addition to genetic factors, other causative factors have been suggested, including exposure to various infections during pregnancy and endocrinological abnormalities during development.
With respect to SOD, as previously eluded to earlier, the condition arises from abnormalities during embryological development. The exact cause of SOD is poorly understood; although it is likely genetic factors play an important role, with various patients exhibiting mutations in the genes HESX1, OTX2, and PAX6. In addition, exposure to certain medications, such as sodium valproate during pregnancy, is thought to play an important role in the development of SOD.

How are ONH and SOD diagnosed?
Diagnosis of ONH requires confirmation with ophthalmoscopic examination of the optic optic disc. In young children, the optimal method for diagnosing ONH is with direct ophthalmoscopy, and patients exhibit a small optic disc. SOD is differentiated by the use of MRI scans showing midline brain abnormalities such as corpus callosum hypoplasia or pituitary abnormalities1.

What are the current treatments for ONH and SOD?
Currently, no treatments exist that can cure or reverse the symptoms exhibited by patients with ONH and SOD. The treatment for ONH is directed toward the specific symptoms exhibited by each individual. Treatment often necessitates coordinated efforts of a team of specialists including pediatricians, ophthalmologists, neurologists, endocrinologists and other health care professionals. Hormone deficiencies are treated with hormone replacement therapy, often directed by endocrinologists. However, vision abnormalities are usually not treatable in both ONH and SOD patients, although patients may seek help from low vision specialists.

References

  1. Júlio C. Voltarelli; Carlos E. B. Couri; Ana B. P. L. Stracieri; et al. Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus. JAMA. 2007;297(14):1568-1576.
  2. Giselle Chamberlain, James Fox, Brian Ashton et al. Concise Review: Mesenchymal Stem Cells: Their Phenotype, Differentiation Capacity, Immunological Features, and Potential for Homing. STEM CELLS 2007;25:2739 –2749.
  3. Myoung Woo Lee • In Keun Jang • Keon Hee Yoo et al. Stem and progenitor cells in human umbilical cord blood. Int J Hematol (2010) 92:45–51.
  4. Cun-Gang Fan & Qing-jun Zhang & Jing-ru Zhou. Therapeutic Potentials of Mesenchymal Stem Cells Derived from Human Umbilical Cord. 2010. Stem Cell Rev and Rep 9168-8.
  5. David T. Harris. Cord Blood Stem Cells: A Review of Potential Neurological Applications. Stem Cell Rev (2008) 4:269–274.
  6. Annegret Dahlmann-Noon et al. Current approaches and future prospects for stem cell rescue and regeration of retina and optic nerve. can J Ophthalmol 2010;45:333-41.
  7. Naoko Koike Kiriyama et al. Human cord blood stem cells can differentiate into retinal nerve cells. Acta Neurobiol Exp 2007, 67;359-365.
  8. Rubens Camargo SiqueiraI; Júlio Cesar Voltarelli; André Marcio Vieira Messias; Rodrigo Jorge. Possible mechanisms of retinal function recovery with the use of cell therapy with bone marrow-derived stem cells.
  9. Tantai Zhao & Yunqin Li & Luosheng Tang et al. Protective effects of human umbilical cord blood stem cell intravitreal transplantation against optic nerve injury in rats. Graefes Arch Clin Exp Ophthalmol DOI 10.1007/s00417-011-1635-7.
  10. Yiming Huang & Volker Enzmann & Suzanne T. Ildstad. Stem Cell-Based Therapeutic Applications in Retinal Degenerative Diseases. Stem Cell Rev and RepDOI 10.1007/s12015-010-9192-8.
  11. Pinilla I, Martin Nieto J, Cuenca N. Stem Cell Potential Uses in Retinal Dystrophies. Arch Sic Esp Oftalmol 2007; 82: 127-128.