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Stem Cell Treatment for Optic Nerve Atrophy (ONA)

A combination of stem cells and extensive therapies giving the patient real chances of improvement

How does stem cell therapy work?

Since 2007, we have been developing comprehensive stem cell treatment protocols for optic nerve atrophy (ONA) to overcome the limitations of conventional therapies.

In our protocols, stem cells are combined with specialized therapies for ONA that not only focus on helping the patient to cope with their symptoms, but also treat the root cause of the condition by promoting the healing of the optic nerve. We believe that our comprehensive treatment approach for ONA gives our patients the best chances for vision improvement, allowing for a better quality of life. 

Repair optic nerve atrophy using stem cells

The optic nerve acts as a signal transmission channel between the retina in the eye and the visual cortex in brain. When the optic nerve is damaged (atrophy), visual signals become unable to travel freely to the brain and the patient gets affected by partial or total loss of vision.

It is important to remember that optic nerve atrophy can arise from various demyelinating, inflammatory, ischemic or traumatic origins, and conditions such as open angle glaucoma, optic neuritis or Leber hereditary optic neuropathy are among the various causes of ONA. In some cases, the optic nerve atrophy is causing a constant and progressive loss of vision.   

Few conventional treatment options are available for patients diagnosed with ONA, which mostly focus on helping the patients to cope with their disability. However, none of them are actually treating the loss of optic nerve function. Stem cells have the ability to regenerate nerve cells in the optic nerve, allowing ONA patients to recover some vision.  

Patient Case Study
Age: 24 years old / Sex: Female / Nationality: Irish / Date of Admission: January 21, 2010 / Date of Discharge: March 6, 2010 / Diagnosis on Admission: Optic Atrophy and Bilateral Optic Neuropathy / Stem Cell Type: (UC-MSC)
See Case Study
Patient Case Study
Age: 15 years old Sex: Female Nationality: American Date of Admission: July 6, 2008 Date of Discharge: August 11, 2008 Diagnosis on Admission: Optic Nerve Hypoplasia Stem Cell Type: (UCBSC) Stem cells
See Case Study
Patient Case Study
Age: 65 years old / Sex: Male / Nationality: French / Date of Admission: May 8, 2012 / Date of Discharge: May 22, 2012 / Diagnosis on Admission: Optic Neuropathy / Stem Cell Type: (UCBSC) Stem cells
See Case Study
Patient Case Study
Age: 39 years old / Sex: Female / Nationality: South African / Date of Admission: February 10, 2011 / Date of Discharge: February 26, 2011 / Diagnosis on Admission: Open/Wide Angle Glaucoma
See Case Study

What improvements from our treatment?

The purpose of our stem cell treatment is to restore neurological function in the brain/spinal cord lesion area, thus, various kinds of improvement are possible after our treatment and our past patients have experienced the following*:

  • Sharpened visual acuity
  • Enhanced light perception
  • Enlarged visual field
  • Brighter night vision
  • Reduced nystagmus
  • Improved strabismus

It is important to remember that as for any medical treatment, improvements cannot be guaranteed. Please contact us for more information regarding the possible improvements for a particular case.

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Stem Cell Therapy

Our stem cell treatment for Optic Nerve Atrophy (ONA) consist in 6 to 8 simple and minimally invasive injections of umbilical cord derived stem cells. The stem cells are transplanted using three separate methods: by intravenous way using a standard IV drip system, through intrathecal injection performed after lumbar puncture and retrobulbar injections to better target the optic nerves. Together, these 3 delivery methods allow for increased efficacy while ensuring safety and minimum inconvenience for the patient. Read more about each procedure below: Intravenous Injection (IV) >  Intrathecal Injection (LP) >  Retrobulbar Injection (RBI) >

Acupuncture Therapy

Acupuncture is a technique in which practitioners stimulate specific points on the body – most often by inserting thin needles through the skin. It is one of the most effective practices used in traditional Chinese medicine. Acupuncture stimulates nerve fibers to transmit signals to the spinal cord and brain, activating. read more about Acupuncture Therapy

Aquatherapy

Aquatic Physical Therapy is the practice of physical therapy in a specifically designed water pool with a therapist. The unique properties of the aquatic environment enhance interventions for patients with neurological or musculoskeletal conditions. Aquatic therapy includes a wide range of techniques allowing patients to improve their balance, muscle strength. read more about Aquatherapy

Hyperbaric Oxygen Therapy

Hyperbaric Oxygen Therapy (HBOT) is the medical use of oxygen at a level higher than atmospheric pressure. The equipment required consists of pressure chamber, which may be of rigid or flexible construction, and a means of delivering 100% oxygen into the respiratory system. Published research shows that HBOT increases the. read more about Hyperbaric Oxygen Therapy

Nutrition Therapy

Medical nutrition therapy (MNT) is a therapeutic approach to treat medical conditions and their associated symptoms via the use of a specifically tailored diet devised and monitored by a specialist. The therapy aims at fixing nutritional deficiencies and physiological imbalances in order to provide the best environment possible for the. read more about Nutrition Therapy

Transcranial Magnetic Stimulation

Research has shown that TMS can effectively treat symptoms of depression, anxiety, neurological pain, stroke, spinal cord injuries, autism and more. This procedure is very simple and noninvasive. During the procedure, a magnetic field generator or “coil” is placed near the head of the person receiving the treatment. The coil. read more about Transcranial Magnetic Stimulation

Occupational Therapy

Is interventions focus on adapting the environment, modifying the task and teaching the skill, in order to increase participation in and performance of daily activities, particularly those that are meaningful to the patient with physical, mental, or cognitive disorders. Our Occupational Therapists also focus much of their work on. more about Occupational Therapy

Physical Therapy

Physical therapy or physiotherapy (often abbreviated to PT) is a physical medicine and rehabilitation specialty that, by using mechanical force and movements, remediates impairments and promotes mobility, function, and quality of life through examination, diagnosis, prognosis, and physical intervention. We combine our PT with stem cells for maximum physical rehabilitation. read more about Physical Therapy

Nerve Growth Factor (NGF)

Is a member of the neurotrophic factor (neurotrophin, NTFS) family, which can prevent the death of nerve cells and has many features of typical neurotransmitter molecules. NGF plays an important role in the development and growth of nerve cells. NGF is synthesized and secreted by tissue. read more about Nerve Growth Factor (NGF)

Why Choose Beike Biotech?

Experience: With more than a decade of practice, you are ensured to be advised and treated by competent professionals. 

Safety: Accredited by the American Association of Blood Banks (AABB) and following highest international standards, our stem cell processing methods and laboratories ensure that you receive the best stem cell quality available. 

Diversity: Multiple types of stem cells having different capabilities are available to adapt to each patient’s specific condition. We do not use the same type of stem cells for all patients.

Extensiveness: A complete supportive therapy program is provided daily to stimulate patient’s freshly transplanted stem cells. The best improvement can only be obtain by supporting your stem cells.

Support: A full follow-up program is provided after the treatment and you will be asked to take part in it at 1, 3, 6 and 12 months after treatment. Access to our team after the treatment is very important as you may receive further advice to maximize improvements.

Treatment Location: Bangkok, Thailand

Beike Building

Learn More About Us

Founded in July 2005, Shenzhen Beike Biotechnology Co. Ltd. (hereinafter referred to as Beike Biotechnology) is a national high-tech enterprise specialized in clinical transformation and technical service of biological treatment technology of strategic emerging industries. About Us

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What is optic nerve atrophy (ONA)?

Optic nerve atrophy (ONA) is an umbrella term used to describe a number of conditions, which result in vision loss. Optic nerve atrophy can be classified according to the cause of the atrophy, accordingly: 

  • Demyelinating
  • Inflammatory
  • Ischemic
  • Traumatic

What causes Optic nerve atrophy?

The cause of ONA is dependent upon the type of atrophy present:

  • Demyelinating ONA, also known as optic neuritis, occurs in conditions such as multiple sclerosis and other demyelinating and inflammatory conditions. Patients often present with rapid loss of vision in one eye, which may be loss in part or all of the visual field.
  • Ischemic ONA results from occlusion of blood vessels supplying the optic nerve and can occur in conditions such as vasculitis, giant cell arteritis, granulomatosis with polyangiitis, and rheumatoid arthritis. Patients with ischemic ONA develop rapidly progressing loss of vision, often in the superior aspect of their visual field.
  • Traumatic ONA results from direct injury to the optic nerve, often from blunt force or accidents such as motor vehicle collisions.
  • Inflammatory ONA, also known as infiltrative neuropathy, results in destruction of the optic nerve from locally invading tumors, infection and autoimmune processes such as sarcoidosis. 

How is Optic nerve atrophy diagnosed?

ONA is diagnosed by extensive ophthalmological investigation which may include1:

  1. Visual field testing: visual field defects in optic neuropathies can take several patterns including central, diffuse, arcuate, and altitudinal defect. The pattern of visual filed defect is not specific of any etiology and almost any type of field defect can occur with any optic neuropathy. However, altitudinal defects are more common in ischemic optic neuropathies and central, or cecocentral defects frequently accompany toxic/nutritional and hereditary optic neuropathies.
  2. Electrophysiological testing: Visual evoked potential (VEP) are often abnormal in optic neuropathies. Although VEP is not necessary in the diagnosis of optic neuropathy, it can be useful in patients with early or sub-clinical optic neuropathy who may have normal pupillary responses and no discernible optic disc changes on clinical examination
  3. Optical coherence tomography: a relatively new technique which uses low coherence light to penetrate tissue and a camera to analyze the reflected image. By performing circular scans around the optic nerve head, the peripapillary nerve fiber layer can be analyzed. This has been useful in the follow up of patients with optic neuritis, traumatic optic neuropathy, and Leber’s hereditary optic neuropathy

Symptoms of ONA often include tunnel vision (also known as scotoma), blurred vision, and loss of other visual fields. These defects are diagnosed on further investigation using the aforementioned techniques.

What are the current treatments for Optic nerve atrophy?

Currently, there are no effective treatments for ONA. Following destruction of the optic nerve, regeneration of neurons using conventional medical treatment is not possible. Therefore, treatment with novel therapies, such as stem cells, offers a promising hope that regeneration of vision in ONA patients may be a possibility.

How can stem cell treatment restore vision in patients?

The mechanisms by which stem cells deliver their regenerative action are :

  • Secretion of neurotrophic factors before or after differentiation. MSCs release certain neurotrophic growth factors including brain derived neurotrophic factor (BDNF) which may offer neuroprotection.
  • Injection of MSC may result in anti-inflammatory effects, thereby increasing regeneration of neurons located within the optic nerve.
  • Studies in mice have shown that injection of MSCs provided by intravitreal injection were shown to migrate to the surface of the retina and integrate into the nerve fiber layer ultimately forming the optic nerve.
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