How effective is it to use a donor’s stem cells?

⏲️2 minutes read

To answer this question, it is necessary first to understand how stem cells function. Generally, stem cells perform regenerative functions via two distinct mechanisms: direct differentiation and paracrine signaling.

While direct differentiation refers to a stem cell’s ability to directly differentiate and replace damaged cells, paracrine signaling refers to the process by which stem cells release factors that act as signals for neighboring cells. The “signaling” causes other cells in the vicinity to change their behavior, kicking off the regeneration process.

In a large number of studies about stem cell transplants, researchers observed that damaged patient issues were repaired after a stem cell transplant from a donor. However, after examining the newly generated tissues, it was discovered that the donor cells were missing.

Scientists were then able to demonstrate that the donor stem cells were secreting factors that triggered the patient’s own cells to repair the tissues. It has been demonstrated that the majority of regeneration occurs via paracrine signaling rather than direct differentiation. Another important function of stem cell paracrine signaling is immune system modulation to combat autoimmune diseases.

The most important fact is that despite their short lifespan, stem cell donors have a long-lasting effect on tissue regeneration that lasts long after the donor stem cells have been depleted.

Can I use my own core blood for my stem cell therapy?

We are unable to treat patients using their own cord blood due to regulatory and efficacy concerns. One sample of cord blood will typically not be sufficient to treat a patient’s condition, because only one injection worth of mononuclear cells is present in a single sample of cord blood. Typically, a Beike Stem Cell therapy involves six to eight stem cell injections.