Restoring Neurological Function in Cerebral Palsy Patients Using Stem Cells
Few conventional treatment options are available for patients diagnosed with cerebral palsy, which mostly focus on helping the patients to cope with their disability. However, none of these other options are actually treating the loss of neurological function caused by the original cerebral injury. Stem cell treatment for cerebral palsy has the ability to regenerate injured cells in the body, helping to reverse the symptoms and allowing cerebral palsy patients to improve.
What is cerebral palsy?
Cerebral palsy is an umbrella term for many possible symptoms that arise as a result of damage to a developing brain in the cerebral hemispheres, responsible for controlling movement, speech, learning, and more. This brain injury is acquired before, during, or shortly after birth and considered non-progressive. The symptoms can include but are not limited to muscle weakness, general motor control problems, eating, swallowing, coordination, and even problems with cognitive function.
Specific causes could be from the brain developing in an unusual way, infections during pregnancy, physical injury, complications in premature birth, critical illness at birth, lack of oxygen to the brain (hypoxia/anoxia), neonatal jaundice and kernicterus, etc. This is not an exhaustive list. There are many other possible causes that can be in any combination to cause the symptoms experienced by one person. It is important to understand that because cerebral palsy is largely an umbrella term and is defined based on the result of the condition rather than the specific cause, no two cerebral palsy patients suffer in exactly the same way.
How can stem cells help?
Due to the nature of the condition, (many patients with the same condition but different causes), improvements in cerebral palsy patients can be difficult with conventional treatment, and damage is often viewed as irreversible. Injury is usually a one-time event, and the resulting condition is because the immune system is unable to fix or reverse what damage was done.
Stem cells are responsible for differentiating into new cells when old ones die or are damaged. They are able to become skin, blood, muscle, bone, and more. One of the cells they can become are neurons in the brain. This creation of new cells is the source of healing, regrowth, and continued life. A stem cell treatment, by injecting concentrated, potent stem cells into the body, is able to stimulate the immune system, providing an extra boots and helping create new cells that the body needs. For neurological conditions, the most important area to send stem cells to is the brain, so that new neurons may be created for proper brain function. Stem cell treatment for cerebral palsy is more effective in younger children because the body is still growing, attempting to heal the damaged brain, and also learning to adapt around this injury to achieve maximum brain function.
This trial shows both the safety and efficacy of using human umbilical cord mesenchymal stem cells (MSC) in children with cerebral palsy. Full study here.
“Conclusion: Using cord blood stem cells to treat CP can improve gross motor function while not causing any harmful effects to immune-system functions.” Full study here.
“Conclusion: This study highlights that cells found in UCB is able to mediate neuroinflammation and is an effective neuroprotective therapy. Our study also shows that particular cells found in UCB, namely EPCs, may have an added advantage over using UCB alone. This work has the potential to progress towards tailored UCB therapies for the treatment of perinatal brain injury.” Full study here.
“The results confirm that multiple intravenous infusions of allogeneic AB0/Rh-identical UCB cells may be a safe and effective procedure
and could be included in treatment and rehabilitation programs for juvenile patients with cerebral palsy.” Full study here.
Study shows that among 47 patients, no serious adverse effects were recorded, and milder adverse effects were not shown to be related to stem cell treatments. Full study here.
“Without question, stem cells therapies hold promise for the treatment of a wide range of neurological disorders, including for the treatment of perinatal brain injuries.” Full study here.
Conclusion: “Given that inflammation plays a pivotal role in CP, our results suggest that allogeneic hUCBCs therapy may be an appropriate strategy for CP treatment.” Full study here.
Conclusion: “The clinical application of hUC-MSCs combined with basic rehabilitation treatment was effective and safe for improving motor and comprehensive function in a patient with CP.” Full study here.
Patients Like You
Cerebral Palsy Patient Sees Improvements After Stem Cell Therapy News Samuel and his family recently came back for a second round of treatment with Beike stem cells. When Samuel was born in Portugal in 2013, he was diagnosed with cerebral palsy as a result of neonatal hypoglycemia, which is a blood sugar
Stem Cell Treatment For Cerebral Palsy Patient UK Enzo flew from the UK to Bangkok for the first time in 2016 at only 3 years old. Born with quadriplegic cerebral palsy due to trauma caused during labor, his parents hoped they could do anything to improve their son’s quality of
Yusuf Tas was born just a over a year and a half ago with cerebral palsy, a condition that affects from 1.5 to more than 4 per 1,000 live births globally and is the most common motor disability in children. Yusuf’s major symptoms included an inability to express himself outside
Below are video interviews recorded during treatment with Beike stem cells. The families showcased in these videos talk about their personal stories and their experience of the treatment including the improvement noticed. The improvements mentioned in these videos are typical, however it does not guarantee that all patients may have the same improvements.
FAQ About Cerebral Palsy and Stem Cells
Current treatment for cerebral palsy consists of medication as well as physical and occupational therapy. However, these treatments are intended only to mitigate symptoms and make them more manageable, and do not address the root cause, which is considered complete and irreversible. Stem cells, by addressing the injury obtained in cerebral hemispheres, are able to not only lessen symptoms, but actually reverse some of the original damage and create lasting developments in a child with cerebral palsy.
Right now there is no cure for cerebral palsy. Traditional methods of treatment are able to help manage symptoms. The purpose of stem cell therapy is to restore neurological function in the brain and spinal cord lesion area, and therefore reduce and actually reverse some of those symptoms. However, though these results can be life changing and lasting, this does not count as a “cure” and some milder symptoms will likely remain.
Our patients have experienced improvements that include but are not limited to:
There are five main points that can be made of the benefits of stem cells for cerebral palsy patients:
1. Reducing the inflammation response, avoiding secondary brain lesion;
2. Differentiating into astrocyte, microglia, oligodendrocyte, neuron and glia cells, which may be good for myelin sheath, axon regeneration, transmission of nerve impulse
3. Producing the cytokines and growth factors, such as glial derived neurotrophic factor (GDNF), brain derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin 3(NT-3), and neurotrophin 4/5 (NT 4/5) that support brain neuroprotection;
4. Generating new vessel growth, thereby increasing the delivery of oxygen and nutrients to injured and hypoxic tissue;
5. Reducing the intrinsic cell apoptosis (reducing cell death).
Only few patients have side effects after stem cell injections. Side effects appear right after injection and can include headache, fever, nausea, dizziness, vomiting or pain in the legs. Side effects are temporary and fade away quickly in most cases.
Don’t see your question? Ask us here!
Fill in the contact form and we will get back to you as soon as we can.
Interested In Our Treatment?
Get a free medical evaluation of you or your loved one's condition - without commitment.
We will put you in touch with one of our specialists to see if our
stem cell treatment could be right for you.
Fill out of the form to get in touch with one of our specialists and receive a free medical evaluation.
Find out if you qualify for our stem cell treatment and learn about your customized treatment plan.
If you decide to continue, register for our program and embark on your stem cell treatment journey.