English
中文繁體
Español
Français
Polski
Português
Română
Русский

Stem Cell Treatment for Cerebral Palsy CP

A combination of stem cells and extensive therapies giving the patient real chances of improvement

Cerebral Palsy

Restoring Neurological Function in Cerebral Palsy Patients Using Stem Cells

Few conventional treatment options are available for patients diagnosed with cerebral palsy, which mostly focus on helping the patients to cope with their disability. However, none of these other options are actually treating the loss of neurological function caused by the original cerebral injury. Stem cell treatment for cerebral palsy (CP) has the ability to regenerate repair damaged cells in the body, helping to reverse the symptoms and allowing cerebral palsy patients to improve.

What is cerebral palsy?

Cerebral palsy is an umbrella term for many possible symptoms that arise as a result of damage to the developing brain in the cerebral hemispheres, responsible for controlling movement, speech, learning, and more. This brain injury is acquired before, during, or shortly after birth and considered non-progressive. The symptoms can include but are not limited to muscle weakness, general motor control problems, eating, swallowing, coordination, and even problems with cognitive function.

Specific causes could be from the brain developing in an unusual way, infections during pregnancy, physical injury, complications in premature birth, critical illness at birth, lack of oxygen to the brain (hypoxia/anoxia), neonatal jaundice and kernicterus, etc. This is not an exhaustive list. There are many other possible causes that can be in any combination to cause the symptoms experienced by one person. It is important to understand that because cerebral palsy is largely an umbrella term and is defined based on the result of the condition rather than the specific cause, no two cerebral palsy patients suffer in exactly the same way.

How can stem cells help cerebral palsy?

Due to the nature of the condition, (many patients with the same condition but different causes), improvements in cerebral palsy patients can be difficult with conventional treatment, and damage is often viewed as irreversible. Injury is usually a one-time event, and the resulting condition is because the immune system is unable to reverse or repair damaged brain cells.

Stem cells are responsible for differentiating into new cells when old ones die or are injured. They are able to become skin, blood, muscle, bone, and more. One of the cells they can become are neurons in the brain. This creation of new cells is the source of healing, regrowth, and continued life. A stem cell treatment, by injecting concentrated, potent stem cells into the body, is able to stimulate the immune system, providing an extra boost and repair damaged brain cells as well as create new cells that the body needs. For neurological conditions, the most important area to send stem cells is the brain, so that new neurons may be created for proper brain function. Stem cell treatment for cerebral palsy is more effective in younger children because the body is still growing, attempting to repair damaged brain cells, and also learning to adapt around this injury to achieve maximum brain function.

What causes cp? 

There are a number of causes that could result in the symptoms of CP. Some of the possible causes and contributing factors that often afflict people include:

  • The brain developing in an unusual way
  • The genes themselves experiencing change that impacts the brain’s cells development
  • Infections that happen during pregnancy
  • Physical injury causing brain damage that takes place before, during, or after birth
  • Complications in premature birth
  • Critical illness at birth (subnormal consciousness, seizure, etc)
  • A shortage or total lack of oxygen to the brain during or shortly after birth (hypoxia/anoxia)
  • Neonatal Jaundice and Kernicterus

How do you know if you have cerebral palsy?

There are many different cells in the brain that are involved in neurological function, allowing the brain and the rest of the body to communicate properly. There are neurons, astrocytes, microglia, oligodendrocytes, ependymal cells, and many more that are needed to make these connections. The way cerebral palsy exhibits itself can be a result of any or all of these cells being damaged, and can depend on which area of the brain is injured. Cerebral palsy can affect the whole body, including speech, motor and cognitive function, just the legs (paraplegia/paraparesis), or one side of the body (hemiplegia/hemiparesis), but this is not an exhaustive list. The physical effects can be categorized in four main forms, seen below:

Stem Cell Treatment for Cerebral Palsy
Types of CP - Stem Cell Treatment for Cerebral Palsy

Beyond these areas of the body CP can affect, it also can be categorized in the way it affects those areas. This categorization comes in three main forms:

  1. Spastic: this is the most commonly seen form, in which muscle tone is increased, causing muscles to feel stiff and movements to look jerky.
  2. Dyskinetic: this form causes involuntary movements that can be twisting, repetitive, slow, or unpredictable. This affects 10-15% of cases and can be very severe.
  3. Ataxic: this form is characterized by shaky movements that can cause problems with balance, coordination, spatial positioning, posture, and even the control of eye movements. 5% of cerebral palsy patients have this.
  4. Any mixture of these three forms is possible as well.Diagnosis is generally determined after doctors look at an MRI of the patient’s brain coupled with observed symptoms. The patient is also tracked throughout childhood to monitor the pace of important developmental milestones such as crawling and walking.

How is cerebral palsy treated?

As of now, there is no cure for cerebral palsy (CP). Therapies that treat cerebral palsy are for the purpose of helping to mitigate and make symptoms more manageable, especially in terms of making communication less difficult. There are a number of different areas within the disease that can be helped, and often a cerebral palsy patient will work with many types of doctors to improve on many fronts. Medications exist for patients that have need to relax stiff muscles, and to address some feeding problems in babies. Physical therapy and occupational therapy can help improve a patient’s mobility or ability to perform daily tasks, and speech therapy can be used to improve communication skills. For the most part, therapy and medications are viewed as positive interventions to manage the condition, but as in all areas of medicine, some uncertainty and disagreement exists about what and when is best. One of the more new and promising treatments, however, is stem cell treatment for cerebral palsy.

Stem cells for cerebral palsy

There have been many studies done on cell therapies for cerebral palsy, and clinical trials have shown that stem cells have been effective in improving CP symptoms.1One of the most impressive studies to date on stem cell treatment for cerebral palsy is from Duke University in the United States. Duke conducted a randomized study of 63 CP children with different varieties and severities of spastic cerebral palsy. The children’s parents had placed their child’s cord blood stem cells in a blood bank after birth, and after the children were treated with their own cord blood cells, they were shown to see improvements in their motor function just a year later. These improvements were better than those of other CP children of similar age and condition, and better than those that were given fewer stem cells or none at all. One of these children’s stories can be found here. Senior author of the study Joanne Kurtzberg, M.D., is the director of Duke’s Pediatric Blood and Marrow Transplant Program and the Robertson Clinical and Translational Therapy Program. She strongly believes in stem cell treatment for cerebral palsy, saying, “previous research has indicated it’s safe for children with cerebral palsy to receive an infusion of their own cord blood.

Using adult stem cells to treat cerebral palsy

One of the most promising stem cell treatments come from umbilical cord-derived stem cells, including mesenchymal stem cells (MSC), hematopoietic stem cells (HSC), endothelial progenitor cells (EPC), and others. These adult stem cells are able to differentiate into different types of cells, such as osteocytes (bone marrow), chondrocytes (cartilage), myocytes (muscle), fibroblasts (tendon/ligament), adipocytes (fat), hepatic stellate cells (liver), endothelial cells (blood vessels), all blood cells, connective tissues, and more. They are even found to create neurons and glial cells. 2These cells are also able to release products such as cytokines and growth factors that contribute to neural protection,3 and when injected into the brain can stimulate the body’s own repairing of damaged neural cells.The collection of stem cells for treatment can be done in many ways. It could come from fat, bone marrow, umbilical cords, and more. It could come from the patient’s own body (autologous) or from a donor (allogenic). For CP patients, the most common method of injecting stem cells for treatment is either through an intravenous infusion into the bloodstream (an IV), or intrathecal injection below the spinal cord.While IV injections are a more systemic delivery aiming for cell generation in various areas of the body, the spinal cord injection can help the stem cells reach the brain better.

Positive results​

Stem cell treatment for cerebral palsy combined with rehabilitation has shown positive results and is the most commonly preferred option. This combination method was used for the study as well. The graphs of the changes in the Gross Motor Function Measure (GMFM-88) score (the measurement tool for severity of CP in terms of motor function) and the comprehensive functional assessment (CFA) score (a more comprehensive measurement that includes cognizance and comprehension) can be seen in the graphs below.

Stem Cell-Treatment-for-Cerebral-Palsy

It can be seen from the graphs that the more comprehensive scale of measurement, the CFA, showed stronger improvements, telling us that stem cells strongly influence cognitive function as well:

Stem Cell-Treatment-for-Cerebral-Palsy

Clinical Trials

This trial shows both the safety and efficacy of using human umbilical cord mesenchymal stem cells (MSC) in children with cerebral palsy. Full study here

“Conclusion: Using cord blood stem cells to treat CP can improve gross motor function while not causing any harmful effects to immune-system functions.” Full study here

“Conclusion: This study highlights that cells found in UCB is able to mediate neuroinflammation and is an effective neuroprotective therapy. Our study also shows that particular cells found in UCB, namely EPCs, may have an added advantage over using UCB alone. This work has the potential to progress towards tailored UCB therapies for the treatment of perinatal brain injury.” Full study here.

“The results confirm that multiple intravenous infusions of allogeneic AB0/Rh-identical UCB cells may be a safe and effective procedureand could be included in treatment and rehabilitation programs for juvenile patients with cerebral palsy.” Full study here.

Study shows that among 47 patients, no serious adverse effects were recorded, and milder adverse effects were not shown to be related to stem cell treatments. Full study here.

“Without question, stem cells therapies hold promise for the treatment of a wide range of neurological disorders, including for the treatment of perinatal brain injuries.” Full study here.

Conclusion: “Given that inflammation plays a pivotal role in CP, our results suggest that allogeneic hUCBCs therapy may be an appropriate strategy for CP treatment.” Full study here.

Conclusion: “The clinical application of hUC-MSCs combined with basic rehabilitation treatment was effective and safe for improving motor and comprehensive function in a patient with CP.” Full study here.

Case studies

At Stem Cell Treatment Now, among our 22,500+ patients, we have had a large number of cerebral palsy patients join our program for treatment. Our results regarding stem cell treatment for CP can be seen in the two graphs below. The first shows the improvements at the 6 month mark after discharge, which is measured by the most common symptoms experienced by CP patients. Of course, not all symptoms apply to all patients, therefore the numbers can be uneven across symptoms.  

Cp-patient-after-stem-cell-treatment-improvements
Cp-patient-after-stem-cell-treatment-improvements

Patient Stories

5 Improvements After Stem Cell Transplant

A Difficult Start  Zuzanna was born with cerebral palsy (CP), a condition that results after damage to the cerebral hemispheres. This damage happens before, during, or shortly after birth. Zuzanna, lovingly referred to as Zuza, has spent her life dependent on her family, quadriplegic and also epileptic. Before hearing about

Read More »
Cerebral-Palsy-Patient-Sees-Improvements

Cerebral Palsy Patient

Cerebral Palsy Patient Sees Improvements After Stem Cell Therapy Samuel and his family recently came back for a second round of treatment with Beike stem cells. When Samuel was born in Portugal in 2013, he was diagnosed with cerebral palsy as a result of neonatal hypoglycemia, which is a blood sugar deficiency

Read More »
Child with CP Sees Improvements, Decides To Return

Child with CP Sees Improvements, Decides To Return

Stem Cell Treatment For Cerebral Palsy Patient UK  Enzo flew from the UK to Bangkok for the first time in 2016 at only 3 years old. Born with quadriplegic cerebral palsy due to trauma caused during labor, his parents hoped they could do anything to improve their son’s quality of

Read More »

FAQ About Stem Cell Treatment for Cerebral Palsy

Current treatment for cerebral palsy consists of medication as well as physical and occupational therapy. However, these treatments are intended only to mitigate symptoms and make them more manageable, and do not address the root cause, which is considered complete and irreversible. Stem cells, by addressing the injury obtained in cerebral hemispheres, are able to not only lessen symptoms, but actually reverse some of the original damage and create lasting developments in a child with cerebral palsy.

Right now there is no cure for cerebral palsy. Traditional methods of treatment are able to help manage symptoms. The purpose of stem cell therapy is to restore neurological function in the brain and spinal cord lesion area, and therefore reduce and actually reverse some of those symptoms. However, though these results can be life changing and lasting, this does not count as a “cure” and some milder symptoms will likely remain. 

Our patients have experienced improvements that include but are not limited to:

  • Better balance and coordination
  • Reduced fatigue
  • Improved speech
  • Decreased tremors
  • Improved motor function
  • Better swallowing
  • Decreased neuropathic pain
  • Improved mental alertness

It is important to note that, as for any medical treatment, improvement cannot be guaranteed. 

There are five main points that can be made of the benefits of stem cells for cerebral palsy patients:

1. Reducing the inflammation response, avoiding secondary brain lesion;

2. Differentiating into astrocyte, microglia, oligodendrocyte, neuron and glia cells, which may be good for myelin sheath, axon regeneration, transmission of nerve impulse

3. Producing the cytokines and growth factors, such as glial derived neurotrophic factor (GDNF), brain derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin 3(NT-3), and neurotrophin 4/5 (NT 4/5) that support brain neuroprotection;

4. Generating new vessel growth, thereby increasing the delivery of oxygen and nutrients to injured and hypoxic tissue;

5. Reducing the intrinsic cell apoptosis (reducing cell death).

Most of our patients diagnosed with cerebral palsy receive umbilical cord blood stem cells (UCBSC). Only patients with RH negative blood will receive umbilical cord mesenchymal stem cells instead. Both types of stem cells are extracted from umbilical cords gathered from healthy babies after birth.

Only few patients have side effects after stem cell injections. Side effects appear right after injection and can include headache, fever, nausea, dizziness, vomiting or pain in the legs. Side effects are temporary and fade away quickly in most cases.

Our comprehensive stem cell treatment starts at $23,000

Don’t see your question? Ask us here!
Fill in the contact form and we will get back to you as soon as we can.

Cerebral Palsy Infographic

Our Treatment Program in Details

Beike is unlike any other stem cell treatment provider in the world, the reason? Since 2005, we have been developing and optimizing our stem cell treatment protocols with the concept that only a very comprehensive solution can allow our patients to truly benefit from stem cells. We believe that stimulation through various therapies is necessary to enhance stem cell regenerative response, therefore our protocols include daily therapies to support the stem cells. Finally, we provide a wide variety and large quantities of stem cells in order to adapt to each patient specific condition and deliver maximized regenerative potential. Learn more about all the particularities that make our treatment truly comprehensive and unique.

  • 16 to 25 Days Stay
  • IV & Intrathecal Injections
  • UCBSC / UCMSC Cells
  • Daily Therapy Program
  • 120-400 Million Cells
  • Nutrition Program

The Stem Cell Therapy

Stem Cell Therapy

Our stem cell treatment for cerebral palsy program consists of 6 to 8 simple and minimally invasive injections of umbilical cord derived stem cells. The stem cells are transplanted using two separate methods: by intravenous way using a standard IV drip system, and through intrathecal injection performed after lumbar puncture. These two delivery methods allow for increased efficacy while ensuring safety and minimum inconvenience for the patient. Read more about each procedure below:

Intravenous Injection (IV) >    Intrathecal Injection (LP) >

Acupuncture

Acupuncture is a technique in which practitioners stimulate specific points on the body – most often by inserting thin needles through the skin. It is one of the most effective practices used in traditional Chinese medicine. Acupuncture stimulates nerve fibers to transmit signals to the spinal cord and brain, activating … read more

read more

Aquatherapy

Aquatic Physical Therapy is the practice of physical therapy in a specifically designed water pool with a therapist. The unique properties of the aquatic environment enhance interventions for patients with neurological or musculoskeletal conditions. Aquatic therapy includes a wide range of techniques allowing patients to improve their balance, muscle strength … read more

read more

Hyperbaric Oxygen Therapy

Hyperbaric Oxygen Therapy (HBOT) is the medical use of oxygen at a level higher than atmospheric pressure. The equipment required consists of pressure chamber, which may be of rigid or flexible construction, and a means of delivering 100% oxygen into the respiratory system. Published research shows that HBOT increases the … read more

read more

Nutrition Therapy

Medical nutrition therapy (MNT) is a therapeutic approach to treat medical conditions and their associated symptoms via the use of a specifically tailored diet devised and monitored by a specialist. The therapy aims at fixing nutritional deficiencies and physiological imbalances in order to provide the best environment possible for the … read more

read more
Nutritional healthy plate of food

Transcranial Magnetic Stimulation

Research has shown that TMS can effectively treat symptoms of depression, anxiety, neurological pain, stroke, spinal cord injuries, autism and more. This procedure is very simple and noninvasive. During the procedure, a magnetic field generator or “coil” is placed near the head of the person receiving the treatment. The coil … read more

read more

Occupational Therapy

Occupational therapy interventions focus on adapting the environment, modifying the task and teaching the skill, in order to increase participation in and performance of daily activities, particularly those that are meaningful to the patient with physical, mental, or cognitive disorders. Our Occupational Therapists also focus much of their work on … read more

read more

Physical Therapy

Physical therapy or physiotherapy (often abbreviated to PT) is a physical medicine and rehabilitation specialty that, by using mechanical force and movements, remediates impairments and promotes mobility, function, and quality of life through examination, diagnosis, prognosis, and physical intervention. We combine our PT with stem cells for maximum physical rehabilitation … read more

read more

Nerve Growth Factor (NGF)

Nerve growth factor (NGF) is a member of the neurotrophic factor (neurotrophin, NTFS) family, which can prevent the death of nerve cells and has many features of typical neurotransmitter molecules. NGF plays an important role in the development and growth of nerve cells. NGF is synthesized and secreted by tissues … read more

read more
Nerve Growth Factors (NGF)

Interested In Our Stem Cell Treatment?

Get a free medical evaluation of you or your loved one’s condition – without commitment.

We will put you in touch with one of our specialists to see if our stem cell treatment for cerebral palsy could be right for you.

Please include your country code in the phone number
If your diagnosis is not listed, please select 'other'.

Pin It on Pinterest

Share This