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Stem Cell Treatment for Traumatic Brain Injury

A combination of stem cells and extensive therapies giving the patient real chances of improvement

Few conventional treatment options are available for patients diagnosed with a traumatic brain injury. However, stem cells offer the chance of treating the loss of neurological function caused by the second wave of injury. Stem cell treatment for TBI has the ability to regenerate injured cells in the body, helping to reverse some symptoms and prevent further damage caused by secondary injury.

What is a traumatic brain injury?

Traumatic brain injury is a result of disruption or loss of function in the brain as a result of outside mechanical force impacting the skull and brain. Automobile accidents, falls, assaults/blows, sports-related injuries, and explosive blasts are some of the most common causes of TBI. Traumatic brain injury starts with a primary brain injury, which is the immediate result of the outside force. This causes focal or diffuse brain injury patterns. However, TBI has a secondary phase of injury that evolves over time. This delayed injury is characterized by a complex cascade molecular and biochemical events that lead to neuroinflammation, brain edema, and delayed neuronal death. 

How can stem cells help?

Stem cells are able to differentiate into all types of cells needed by the body. Different stem cells differentiate into different types of cells, but anytime a new cell is created it is the result of a stem cell. Neurons, however, are a little more difficult to differentiate, and that is why brain injuries don’t typically heal the same way the rest of the body does. To make this a more feasible recovery, sending a mass of stem cells into the spinal cord can create more opportunity for new neurons to be created. By replacing these neurons (and other lost cells) quickly and early, it is possible that further delayed neuronal death can be prevented, avoiding possible delayed injury and symptoms. 

Patient Videos

Below are video interviews recorded during treatment with Beike stem cells. The families showcased in these videos talk about their personal stories and their experience of the treatment including the improvement noticed. The improvements mentioned in these videos are typical, however it does not guarantee that all patients may have the same improvements.

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Clinical Trials and Research

Conclusion: “Autologous BMMNC infusion for adults with severe TBI is safe and logistically feasible.” Full study here.

On page 13: “There was no immediate or delayed toxicity related to the cell administration within the 6-month follow-up period. Neurologic function was significantly improved at 6 months after MSC therapy [162].” Full study here

Conclusion: “Clinical trials have shown that MSC transplantation may decrease TBI patients’ sequela and has the potential to become an effective treatment modality [129]. MSC safety and efficacy have been investigated in patients with complications following TBI [130] and determined that earlier interventions lend themselves to better results.” Full study here

FAQ's about TBI and stem cells

After TBI, people often report symptoms following injury, but improve over time.  The most common symptoms after brain injury are known as post-concussion syndrome (PCS). These symptoms include but may not be limited to:

  • physical complaints (dizziness, fatigue, headaches, visual disturbances, trouble sleeping, sensitivity to light and sound, poor balance),
  • cognitive changes (poor concentration, memory problems, poor judgment and impulsivity, slowed performance, difficulty putting thoughts into words),
  • psycho-social concerns (depression, anger outbursts, irritability, personality changes, anxiety).

Diagnosis of TBI is difficult because affected individuals may not show physical signs of injury. Clinically, doctors will give the diagnosis of TBI on the basis of the history of brain injury and clinical tests, which include EEG, CT scans, MRIs and so on.

The most common symptoms in brain trauma survivors are cognitive deficits and motor dysfunctions. Right now, there is no effective conventional treatment for these symptoms to promote functional recovery except for routine medical intervention and care. Fortunately, there are many promising drug- or cell-based therapeutic approaches emerging recently, including erythropoietin and its carbamylated form, statins, bone marrow stromal cells, hyperbaric oxygen therapy, and so on. These novel treatment methods will reduce brain injury via neuroprotection and promote brain remodeling via angiogenesis, neurogenesis, and synaptogenesis with a final goal to improve the functional outcome of TBI patients.

Majority of treated patients in Beike are suffering with sequelae of traumatic brain injury. They are treated with a variety of cell sources, such as umbilical cord blood stem cells (UCBSCs) and umbilical cord derived mesenchymal stem cells (UC-MSCs). It has been shown that these kinds of stem cells will become a novel therapeutic option for traumatic brain injury.  According to follow-up data, many TBI patients have shown symptom improvements in: 

  • Carrying out of simple activities (41.4%); 
  • Balance (44.8%); 
  • Memory (27.6%); 
  • Concentration (58.6%); 
  • Sleep disturbance (51.7%); 
  • Mood and emotions (41.4%); 
  • Understanding (37.9%) 

However, when discussing improvements, it is important to remember that improvements might differ greatly from one patient to another. This is due to many factors, such as a patient’s medical condition, duration of living with the injury, severity, complications, physical condition, age, and so on. Therefore, improvement cannot be guaranteed.

Stem cell treatment for TBI will focus on secondary brain injury, which is the result of biochemical and physiological events, ultimately leading to neuronal cell death.  Recent research has indicated that the potential therapeutic benefit of stem cell therapy could be the result of the following mechanisms:

  1. Secretion of growth factors to promote functional outcome after brain injury via neurogenesis and synaptogenesis;
  2. Production and inducement of many cytokines and trophic factors to enhance angiogenesis and vascular stabilization in the lesion boundary zone;
  3. Decrease of the glial scar formation and promotion of glial-axonal remodeling. Thus, stem cells act in a pleiotropic way to stimulate brain remodeling after brain injury by influencing several neural restorative functions such as synaptogenesis, angiogenesis, and neurogenesis.

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TBI Traumatic Brain Injury infographic

Our Treatment Program in Details

Beike is unlike any other stem cell treatment provider in the world, the reason? Since 2005, we have been developing and optimizing our stem cell treatment protocols with the concept that only a very comprehensive solution can allow our patients to truly benefit from stem cells. We believe that stimulation through various therapies is necessary to enhance stem cell regenerative response, therefore our protocols include daily therapies to support the stem cells. Finally, we provide a wide variety and large quantities of stem cells in order to adapt to each patient specific condition and deliver maximized regenerative potential. Learn more about all the particularities that make our treatment truly comprehensive and unique.

  • 16 to 25 Days Stay
  • IV & Intrathecal Injections
  • UCBSC / UCMSC Cells
  • Daily Therapy Program
  • 120-400 Million Cells
  • Nutrition Program

The Stem Cell Therapy

Stem Cell Therapy

Our stem cell transplantation program for traumatic brain injury consist in 6 to 8 simple and minimally invasive injections of umbilical cord derived stem cells. The stem cells are transplanted using two separate methods: by intravenous way using a standard IV drip system, and through intrathecal injection performed after lumbar puncture. These two delivery methods allow for increased efficacy while ensuring safety and minimum inconvenience for the patient. Read more about each procedure below:

Intravenous Injection (IV) >    Intrathecal Injection (LP) >

Physical Therapy

Physical therapy or physiotherapy (often abbreviated to PT) is a physical medicine and rehabilitation specialty that, by using mechanical force and movements, remediates impairments and promotes mobility, function, and quality of life through examination, diagnosis, prognosis, and physical intervention. We combine our PT with stem cells for maximum physical rehabilitation … read more

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Occupational Therapy

Occupational therapy interventions focus on adapting the environment, modifying the task and teaching the skill, in order to increase participation in and performance of daily activities, particularly those that are meaningful to the patient with physical, mental, or cognitive disorders. Our Occupational Therapists also focus much of their work on … read more

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Aquatherapy

Aquatic Physical Therapy is the practice of physical therapy in a specifically designed water pool with a therapist. The unique properties of the aquatic environment enhance interventions for patients with neurological or musculoskeletal conditions. Aquatic therapy includes a wide range of techniques allowing patients to improve their balance, muscle strength … read more

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Transcranial Magnetic Stimulation

Research has shown that TMS can effectively treat symptoms of depression, anxiety, neurological pain, stroke, spinal cord injuries, autism and more. This procedure is very simple and noninvasive. During the procedure, a magnetic field generator or “coil” is placed near the head of the person receiving the treatment. The coil … read more

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Hyperbaric Oxygen Therapy

Hyperbaric Oxygen Therapy (HBOT) is the medical use of oxygen at a level higher than atmospheric pressure. The equipment required consists of pressure chamber, which may be of rigid or flexible construction, and a means of delivering 100% oxygen into the respiratory system. Published research shows that HBOT increases the … read more

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Acupuncture

Acupuncture is a technique in which practitioners stimulate specific points on the body – most often by inserting thin needles through the skin. It is one of the most effective practices used in traditional Chinese medicine. Acupuncture stimulates nerve fibers to transmit signals to the spinal cord and brain, activating … read more

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Nerve Growth Factor (NGF)

Nerve growth factor (NGF) is a member of the neurotrophic factor (neurotrophin, NTFS) family, which can prevent the death of nerve cells and has many features of typical neurotransmitter molecules. NGF plays an important role in the development and growth of nerve cells. NGF is synthesized and secreted by tissues … read more

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Nerve Growth Factors (NGF)

Nutrition Therapy

Medical nutrition therapy (MNT) is a therapeutic approach to treat medical conditions and their associated symptoms via the use of a specifically tailored diet devised and monitored by a specialist. The therapy aims at fixing nutritional deficiencies and physiological imbalances in order to provide the best environment possible for the … read more

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Nutritional healthy plate of food

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