What is a traumatic brain injury?
Traumatic brain injury is a result of disruption or loss of function in the brain as a result of outside mechanical force impacting the skull and brain. Automobile accidents, falls, assaults/blows, sports-related injuries, and explosive blasts are some of the most common causes of TBI. Traumatic brain injury starts with a primary brain injury / head injury, which is the immediate result of the outside force. This causes focal or diffuse brain injury patterns. However, TBI has a secondary phase of injury that evolves over time. This delayed injury is characterized by a complex cascade molecular and biochemical events that lead to neuroinflammation, brain edema, and delayed neuronal death.
Few conventional treatment options are available for patients diagnosed with a traumatic brain injury. However, stem cells are regenerative medicine which offers the chance of treating the loss of neurological function caused by the second wave of injury. Stem cell therapy for traumatic brain injury TBI has the ability to regenerate injured cells in the body, helping to reverse some symptoms and prevent further damage caused by secondary injury.
How can stem cells help?
Stem cells are able to differentiate into all types of cells needed by the body. Different stem cells differentiate into different types of cells, but anytime a new cell is created it is the result of a stem cell. Neurons, however, are a little more difficult to differentiate, and that is why brain injuries don’t typically heal the same way the rest of the body does. To make this a more feasible recovery, sending a mass of stem cells into the spinal cord can create more opportunity for new neurons to be created. By replacing these neurons (and other lost cells) quickly and early, it is possible that further delayed neuronal death can be prevented, avoiding possible delayed injury and symptoms.
Carlos’ Stem Cell Journey
When Carlos was 12, he suffered a crushing traumatic brain injury. In this interview shot during Carlos’ first round of stem cell transplants, his father discusses the improvements in his condition.
Find out more about patients previously treated with Beike stem cell protocols. The families participating in these blog posts talk about their stories and present their own view of the treatment, including thoughts regarding the daily therapies, the stem cell injection themselves as well as improvement noticed during and after treatment.
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Our Treatment Program in Details
Beike is unlike any other stem cell treatment provider in the world, the reason? Since 2005, we have been developing and optimizing our stem cell treatment protocols with the concept that only a very comprehensive solution can allow our patients to truly benefit from stem cells. We believe that stimulation through various therapies is necessary to enhance stem cell regenerative response, therefore our protocols include daily therapies to support the stem cells. Finally, we provide a wide variety and large quantities of stem cells in order to adapt to each patient specific condition and deliver maximized regenerative potential.
Our stem cell transplantation program for traumatic brain injury consist in 6 to 8 simple and minimally invasive injections of umbilical cord derived stem cells. The stem cells are transplanted using two separate methods: by intravenous way using a standard IV drip system, and through intrathecal injection performed after lumbar puncture. These two delivery methods allow for increased efficacy while ensuring safety and minimum inconvenience for the patient.
- 15 to 23 Days Stay
- IV & Intrathecal Injections
- UCBSC / UCMSC Cells
- Daily Therapy Program
- 120-400 Million Cells
- Nutrition Program
Stem Cell Quality and Quantity Ensured
Different types of stem cells for different needs
Beike provides stem cells from two separate sources: umbilical cord blood and umbilical cord tissue. Umbilical cord related samples are donated by healthy mothers after normal births and are sent to Beike Biotech’s laboratories for processing.
After reviewing the patient’s full medical information, our doctors will recommend which source of stem cells should be used for treatment. Our treatment protocols may include one or multiple types of stem cells in combination depending on each patient’s specific condition.
Highest International Stem Cell Processing Standards
Beike Biotechnology is processing its own adult stem cells in its internationally accredited laboratories. The company has full control over the processing and quality control of all stem cell products, ensuring perfect safety and highest quality. Processing methods and facility are accredited by the American Association of Blood Banks (AABB), the highest international standard in the industry.
Below are video interviews recorded during treatment with Beike stem cells. The families showcased in these videos talk about their personal stories and their experience of the treatment including the improvement noticed. The improvements mentioned in these videos are typical, however it does not guarantee that all patients may have the same improvements.
Why Choose Beike?
Experience: With more than a decade of practice, you are ensured to be advised and treated by competent professionals.
Safety: Accredited by the American Association of Blood Banks (AABB) and following highest international standards, our stem cell processing methods and laboratories ensure that you receive the best stem cell quality available.
Diversity: Multiple types of stem cells having different capabilities are available to adapt to each patient’s specific condition. We do not use the same type of stem cells for all patients.
Extensiveness: A complete supportive therapy program is provided daily to stimulate patient’s freshly transplanted stem cells. The best improvement can only be obtain by supporting your stem cells.
Support: A full follow-up program is provided after the treatment and you will be asked to take part in it at 1, 3, 6 and 12 months after treatment. Access to our team after the treatment is very important as you may receive further advice to maximize improvements.
Learn More About Us
Founded in July 2005, Shenzhen Beike Biotechnology is a national high-tech enterprise specialized in clinical transformation and technical service of biological treatment technology of strategic emerging industries.
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Conclusion: “Autologous BMMNC infusion for adults with severe TBI is safe and logistically feasible.” Full study here.
On page 13: “There was no immediate or delayed toxicity related to the cell administration within the 6-month follow-up period. Neurologic function was significantly improved at 6 months after MSC therapy .” Full study here.
Conclusion: “Clinical trials have shown that MSC transplantation may decrease TBI patients’ sequela and has the potential to become an effective treatment modality . MSC safety and efficacy have been investigated in patients with complications following TBI  and determined that earlier interventions lend themselves to better results.” Full study here.
After TBI, people often report symptoms following injury, but improve over time. The most common symptoms after brain injury are known as post-concussion syndrome (PCS). These symptoms include but may not be limited to:
– physical complaints (dizziness, fatigue, headaches, visual disturbances, trouble sleeping, sensitivity to light and sound, poor balance),
– cognitive changes (poor concentration, memory problems, poor judgment and impulsivity, slowed performance, difficulty putting thoughts into words),
– psycho-social concerns (depression, anger outbursts, irritability, personality changes, anxiety).
Diagnosis of TBI is difficult because affected individuals may not show physical signs of injury. Clinically, doctors will give the diagnosis of TBI on the basis of the history of brain injury and clinical tests, which include EEG, CT scans, MRIs and so on.
The most common symptoms in brain trauma survivors are cognitive deficits and motor dysfunctions. Right now, there is no effective conventional treatment for these symptoms to promote functional recovery except for routine medical intervention and care. Fortunately, there are many promising drug- or cell-based therapeutic approaches emerging recently, including erythropoietin and its carbamylated form, statins, bone marrow stromal cells, hyperbaric oxygen therapy, and so on. These novel treatment methods will reduce brain injury via neuroprotection and promote brain remodeling via angiogenesis, neurogenesis, and synaptogenesis with a final goal to improve the functional outcome of TBI patients.
Stem cell therapy for traumatic brain injury TBI will focus on secondary brain injury, which is the result of biochemical and physiological events, ultimately leading to neuronal cell death. Recent research has indicated that the potential therapeutic benefit of stem cell therapy could be the result of the following mechanisms:
1. Secretion of growth factors to promote functional outcome after brain injury via neurogenesis and synaptogenesis;
2. Production and inducement of many cytokines and trophic factors to enhance angiogenesis and vascular stabilization in the lesion boundary zone;
3. Decrease of the glial scar formation and promotion of glial-axonal remodeling. Thus, stem cells act in a pleiotropic way to stimulate brain remodeling after brain injury by influencing several neural restorative functions such as synaptogenesis, angiogenesis, and neurogenesis.