Stem Cell Quality and Quantity Ensured
Different types of stem cells for different needs
Beike provides stem cells from two separate sources: umbilical cord blood and umbilical cord tissue. Umbilical cord related samples are donated by healthy mothers after normal births and are sent to Beike Biotech's laboratories for processing.
After reviewing the patient’s full medical information, our doctors will recommend which source of stem cells should be used for treatment. Our treatment protocols may include one or multiple types of stem cell in combination depending on each patient's specific condition.
Highest International Stem Cell Processing Standards
Beike Biotechnology is processing its own adult stem cells in its internationally accredited laboratories. The company has full control over the processing and quality control of all stem cell products, ensuring perfect safety and highest quality. Processing methods and facility are accredited by the American Association of Blood Banks (AABB), the highest international standard in the industry.
Below are video interviews recorded during treatment with Beike stem cells. The families showcased in these videos talk about their personal stories and their experience of the treatment including the improvement noticed. The improvements mentioned in these videos are typical, however it does not guarantee that all patients may have the same improvements.
Extensiveness: A complete supportive therapy program is provided daily to stimulate patient's freshly transplanted stem cells. The best improvement can only be obtain by supporting your stem cells.
Support: A full follow-up program is provided after the treatment and you will be asked to take part in it at 1, 3, 6 and 12 months after treatment. Access to our team after the treatment is very important as you may receive further advice to maximize improvements.
Learn More About Us
Founded in July 2005, Shenzhen Beike Biotechnology Co. Ltd. (hereinafter referred to as Beike Biotechnology) is a national high-tech enterprise specialized in clinical transformation and technical service of biological treatment technology of strategic emerging industries.
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What is Spina Bifida?
During a fetus’ development in the womb, there is a group of cells called the neural tube that are responsible for forming the spinal cord and the brain. Typically, this should close during development and then be covered by the spine bone to protect the delicate spinal cord. Sometimes, however, it does not close all the way, causing the back bone to be incomplete.
Sometimes this incompletion can be so small and mild that a patient doesn’t even know they have it. However, in severe cases of spina bifida (specifically myelomeningocele), this incompletion causes that area of the spinal cord and all within it to be exposed to the intrauterine environment, which can cause physical damage to the spinal cord. Furthermore, this sac of spinal fluid and the release of cerebrospinal fluid that leaks out results in a change of pressure, which can cause something called hydrocephalus (commonly referred to as water on the brain). Hydrocephalus happens when the spinal pressure changes, and the back of the brain itself is sucked down into the beginning part of the spinal cord. This then blocks the cerebral spinal fluid, which is created in the brain, from going down into the rest of the spinal cord. As a result, fluid builds up in the brain, which can create an enlarged head, cause mental retardation, or even death.
Children with spina bifida may experience other symptoms such as apnea, in which the child can forget to breathe, along with other respiratory problems, incontinence in the bladder and bowels, paralysis in the lower extremities, developed curves in the spine, and talipes (or clubfoot) which results in malformed or underdeveloped feet. Another common side effect, and sometimes what alerts parents to the problem, is hair growth or a dimple (sacral dimple) around the site of the spinal cord opening. This site is called the occulta, meaning “hidden” as the skin covers the spinal opening.
There are three main types of spina bifida:
- Spina bifida occulta (SBO): This is both the most common and most mild form of spina bifida. Also known as “hidden spina bifida,” many people will not even be aware that they have it until they have an X-ray for other reasons because it often does not have symptoms.
- Meningocele: A sac of spinal fluid pushes through an opening in the back. This can have little to no symptoms, or create problems with continence in the bladder and bowels.
Myelomeningocele: This is the most severe form of spina bifida, as there may be multiple locations in the spine that have openings with sacs of spinal fluid poking out. Unlike meningocele, these sacs of spinal fluid also contain part of the spinal cord and nerves, which are usually damaged.
90% of spina bifida cases are discovered during an ultrasound before 18 weeks of pregnancy. Diagnosis is commonly done through a blood screening to test for alpha-fetoprotein (AFP) in the mother’s blood. Babies create this AFP protein that commonly reaches the mother’s bloodstream, but if the level of AFP is too high it could be a sign of spina bifida.
To determine the reason for high levels of AFP, a doctor will have an ultrasound done to confirm the reason. If further testing is needed, a doctor can perform an amniocentesis test in which a part of the amniotic fluid surrounding the baby is tested. If that fluid has a high concentration of AFP as well, it could be because the skin that should cover the spinal cord is not there and is causing a leakage of the baby’s spinal fluid.
MRI and CT scans are also possible tools for post-natal diagnosis.
At Beike, we have created a comprehensive therapy program to best suit patients with spina bifida. Our treatment consists of Umbilical Cord Derived Mesenchymal Stem Cells (UCMSCs) and Umbilical Cord Blood Stem Cells (UCBSCs), with simultaneous physical therapies to help guide the stem cells to the needed area. Umbilical cord-derived stem cells are actually more than just mesenchymal stem cells (MSC), and also include hematopoietic stem cells (HSC), endothelial progenitor cells (EPC), and others. These adult stem cells are able to differentiate into different types of cells, such as osteocytes (bone), chondrocytes (cartilage), myocytes (muscle), fibroblasts (tendon/ligament), adipocytes (fat), hepatic stellate cells (liver), endothelial cells (blood vessels), all blood cells, connective tissues and more. Studies also show that they can create neurons and glial cells.
It is important to mention that to ensure the safety of patients, Beike also only uses adult stem cells as opposed to embryonic stem cells. To read more about the difference between embryonic and adult (also known as somatic) stem cells, click the link here. Furthermore, Beike has been certified for many years by American Association of Blood Banks (AABB), the FDA’s Center for Biologics Evaluation and Research (CBER), and many others. To see a comprehensive list our standards and certifications.
Our patients have seen excellent results after spina bifida stem cell therapy. Below are graphs of our patients’ improvements in both satisfaction and their quality of life:
When a mother learns that her baby has spina bifida, an in depth diagnosis is conducted to determine exactly how severe the spina bifida is for the child, and what treatment options are available or necessary. After a complete diagnosis, the mother can choose if she wants to terminate the pregnancy or proceed with or without treatment. A common method of treatment is to have prenatal surgery. During this surgery, the neurosurgeon will remove the abnormal sac of skin from the nerve tissue, then moves the exposed nerve tissue back into the spinal canal. However, if for whatever reason the mother does not choose to have fetal surgery, babies born with spina bifida can still have postnatal surgery. The surgery is almost exactly the same and with the same goal, just done later for what could be a combination of medical and personal reasons. Mothers will typically have a cesarean section birth so as not to risk further damage to the child and keep the myelomeningocele intact, and surgery will be done within the first two days of the child’s life.
If the child suffers from hydrocephalus, which is common among myelomeningocele patients, doctors will often insert a shunt tube, which will drain fluid from the brain into the abdomen, which can then absorb the fluid. This can help with the symptoms of hydrocephalus, but can have its own complications and will often need to be replaced multiple times throughout a patient’s life.
Stem cell therapy for spina bifida
There has been a lot of excitement surrounding stem cell therapy for spina bifida lately. For instance, doctor Diana Farmer of University of California Davis (UC Davis), successfully treated a pair of English bulldog puppies a few years ago. The puppies were both born with spina bifida, one of the most common birth defects in English bulldogs.
The puppies, Darla and Spanky, received a combined treatment of surgery and stem cells. Farmer, who helped develop the fetal surgery that has been a breakthrough in spina bifida treatment, also suggests using human placenta derived mesenchymal stromal cells (PMSCs). For these two puppies, the surgery was performed after birth, as there is no prenatal testing for spina bifida in dogs. However, the puppies underwent postnatal surgery and received canine PMSCs. Just over a month after receiving their surgery and treatment, Darla and Spanky were walking and running and playing with each other. With the approval of the U.S. Food and Drug Administration, Farmer hopes to proceed with human clinical trials.
This has been a major achievement in spina bifida treatment, and hopefully just the beginning. Stem cells are regenerative in nature, able to differentiate into different types of cells the body needs to use, allowing the body to heal in ways it couldn’t on its own. By injecting stem cells into the injured site of a spina bifida patient, the stem cells can help to heal the opening of the spinal cord. In particular, while the prenatal surgery has been a great way to improve brain development, patients have still struggled with physical movement and incontinence. Stem cells have shown an ability to increase the physical capabilities of spina bifida patients, including muscle strength, incontinence, feeling and sensation, and general motor function.
Another study published in August of 2018 has shown that stem cell therapy for spina bifida has been successful in two patients, aged 14 and 11. Though the study was small, it was promising in that both patients were unable to defecate or urinate on their own until after their stem cell treatments. After treatment, both patients were able to control their bowel movements as well as their urine. A larger study will be done in the future to confirm the efficacy of this treatment, however, this has been a promising breakthrough for spina bifida patients.
Here is a more comprehensive and specific view of the symptoms felt by patients and the improvements they’ve had in each. Of course, not all patients have all symptoms, so some of them were considered “not applicable”:
For a more personal look at what the Beike experience is like, take a look below at some of our patients that have received stem cell treatments over the years and seen improvements in their motor function:
Anastasia (2018) :
If you would like to learn more about our treatment options for spina bifida, please click the link below for a free consultation: