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Cerebral Palsy, Female, 3 years, November 2019

Summary

DiagnosisSexAgeNationality
Cerebral PalsyFemale 3 yearsPolish
InjectionsCell typeAdmission dateDischarge date
8UCMSC2019-11-062019-11-28

Medical history

The patient suffered from respiratory and blood circulation failure at birth leading to ischemic stroke and severe cerebral asphyxia along with cerebral oedema. Brain activity was impaired and the diagnosis of cerebral palsy was engaged.

Condition On Admission

Upon admission, the patient’s general development was delayed and she was unable to roll over, crawl, sit, stand or walk. She could only hold her head for a few seconds while sitting, she could not track things with her eyes due to her nystagmus. She had moderate to severe spasticity in her four limbs and her hand function was poor. She had epileptic seizures up to four times per day and her speech was non-verbal.

Treatment Schedule

The patient received 8 umbilical cord derived mesenchymal stem cell (UCMSC) packets by intravenous (IV) and intrathecal administration, as per the schedule below. In addition to the above mentioned stem cell administrations, the patient also received a daily therapy program including multiple sessions of physiotherapy, occupational therapy, hyperbaric oxygen therapy, transcranial magnetic stimulation and hyperbaric oxygen therapy.

NumberDateCell TypeDelivery MethodSide Effects
12019-11-08UCMSCIntravenous Injectionnone reported
22019-11-11UCMSCIntrathecal Injection &
Intravenous Injection
none reported
32019-11-15UCMSCIntrathecal Injectionnone reported
42019-11-19UCMSCIntrathecal Injectionnone reported
52019-11-22UCMSCIntrathecal Injection &
Intravenous Injection
none reported
62019-11-25UCMSCIntrathecal Injectionnone reported

Condition at discharge

At discharge, some improvements have already been noticed. The patient could hold her head for more than 30 seconds while sitting and she could move her head to follow a light source. In terms of gross motor function, she still needed maximal support due to her abnormal muscle tone, symmetrical tonic neck reflex, poor limb movement, as well as poor neck and trunk control. However, she sometimes tried to roll over on her own. The spasticity in her hands went from moderate/severe to mild/moderate which helped her to better grasp objects with assistance.

Condition 3 months after treatment

At 3 months after discharge, the patient’s family was mentioning that the patient’s head control had improved and that she could grab objects better. The patient’s mother also mentioned: My daughter has seen many positive changes that have even been noticed by physiotherapists and doctors. Head control has improved a lot and we can see a small change for the better in her trunk control. Spasticity has been particularly reduced in her legs. My daughter reacts more to the surrounding world, and a smile appears more often on her face. We also see improvement in appetite and greater ease of feeding. The only thing that worries us is the increase in the number of seizures. However, we hope that this aspect will also improve with time.”

Improvements were progressively and continuously being made.

The family participated in our follow-up evaluation 3 months after discharge. Please see an excerpt of that evaluation below:

SymptomAssessment of Improvement
Improvement in general physical conditionModerate improvement
AppetiteSignificant improvement
BalanceSmall improvement
DroolingSmall Improvement
Head controlSignificant improvement
Involuntary movementsSmall Improvement
Mood disorderSmall Improvement
Range of movementSmall Improvement
SpasticityModerate improvement
SpeechSmall improvement
SwallowingModerate improvement
Trunk muscle strengthModerate improvement
WalkingModerate improvements