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Traumatic Brain Injury, Female, 46 years, February 2018

Summary

Diagnosis Sex Age Nationality
Traumatic Brain Injury Female 46 years Brazil
Injections Cell type Admission date Discharge date
7 UCBSC July 2018 August 2018

Condition on Admission

The patient’s chief complaint was of weakness in all four limbs for more than 20 years. Patient first noted she had a weakness in both his upper limbs in 1987, which was especially evident in her handwriting. The weakness progressively got worse over time. In 1994, she noticed she had problems walking up and down stairs and would trip over herself from time to time; an MRI confirmed a diagnosis of Ataxia. On physical assessment upon hospital admission she was found to have low muscle tone in all limbs with muscle power of 5/5. Coordination tests such as finger-to-nose and heel-to-tibia showed poor coordination and the patient was unable to walk heel-to-toe. Routine examination showed no other abnormalities.

Treatment Schedule

Patient received 6 umbilical cord blood-derived stem cell (UCBSC) packets by intravenous (IV) injection and lumbar puncture (LP), as per the schedule below:

Number Date Cell Type Delivery Method Side Effects
1 13. July 2018 UCBSC Intravenous Injection none reported
2 17. July 2018 UCBSC Intrathecal Injection none reported
3 20. July 2018 UCBSC Intrathecal Injection none reported
4 23. July 2018 UCBSC Intrathecal Injection none reported
5 27. July 2018 UCBSC Intrathecal Injection none reported
6 31. July 2018 UCBSC Intrathecal Injection &
Intravenous Injection		 none reported

Condition 1 month after treatment

Condition 1 months after treatment: ​The patient reported significant improvements at one month after his treatment. She stated, “[I] can walk heel to toe, can do the balancing exercise for longer periods of time, can go up and down stairs with no hands.” She also made comments about the importance of continuing to do daily exercise and how it is becoming easier but also feels that the exercises are essential to aiding his continued improvements.

Condition 12 months after treatment

Condition 12 months after treatment: ​At the 12 month follow up point the patient reported that she was satisfied with the outcome of his treatment which has improved his quality of life and given her moderate improvements overall in his physical condition.

Symptom
Parents’ Assessment of Improvement
Balance
Moderate improvements
Coordination
Moderate improvements
Fine hand movements
Small improvements
Tremors
Not applicable
Control of movement
Moderate improvements
Muscle stiffness
Not applicable
Speech
Moderate improvements
Walking
Moderate improvements
Fatigue
Small improvements
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